Conserved Protein Domain Family
WHSC1_related

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cd05838: WHSC1_related 
Click on image for an interactive view with Cn3D
The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as plasmacytoma. WHCS1 proteins typically contain two copies of the PWWP domain. The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins seem to be nuclear, often DNA-binding, proteins that function as transcription factors regulating a variety of developmental processes.
Statistics
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PSSM-Id: 99899
View PSSM: cd05838
Aligned: 13 rows
Threshold Bit Score: 135.522
Threshold Setting Gi: 115435314
Created: 27-Nov-2007
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
putative
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:putative chromatin binding site
Evidence:
  • Comment:Based on sequence similarity to other PWWP proteins.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                   #   #  #                            #        # #                      
2DAQ_A          9 LHYKQIVWVKLGn-YRWWPAEICNPRSVPlnIQGLKHDl-GDFPVFFF------GSHDYYWVHQGRVFPYVEGDKSFAEG 80
gi 156390320  193 LLYGDIVWVKLGm-YRWWPAMICNPRDVPtnIQSMRHQp-GEFPVMFL------GSHDFYWIHKGRVFSYQDGDKGTESG 264
gi 118101388  907 LRYKQIVWVKLGn-YRWWPAEICNPRSVPlnIQGLKHDi-GDFPVFFF------GSHDYYWVHQGRVFPYVEGDKSFAEG 978
gi 156542877  803 PLYGEVVWVKLGt-YRWWPSVICYPQEIPtnIATRPHKa-GEFCVMFL------GTRDYYWIHRGKAFLYQDGDANTKVI 874
gi 157126101 1033 PLYNEIVWARYGl-FRFWPAITVPPPKVPenIEQKPHNp-WDICIRFF------GTNDYVWINRRRIYLYQEGDSDTNVD 1104
gi 115435314  272 FVLGDVVWARSGkkCPAWPALVIDPLLHAp-RVVLNSCipGALCVMFFgys-nsGLRDYGWVKQGLIFPFVEYLDRFKGQ 349
gi 86278478   875 PKYRDVIWVKLGn-YRWWPAEIRHPKNIPtnIQHLRHEi-GEFPVFFF------GSKDYFWTHQGRVFPYMEGDRGSKYQ 946
gi 91090902  1229 PLYDEIVWVKLGs-FRWWPAVILFPNEVPdnVKNIPHSk-GEFVVKFY------GTYDHYWVGRGRTFLFQEGDRGHSGS 1300
gi 115936704   39 PRYGDIIWVKLGn-YRWWPGRVCNPKDVPqnIQDKTHIv-GEFPVQFF------GSNDYFWTHQGRVFEYQEGDKGSRET 110
gi 158296343  585 PLYNEIVIAKMGs-FRWWPALTLPPSEIPqnMLQLRHKp-SDICVKFF------NTHDMSWLNRKRMYLYQREDSESLDG 656
gi 29427833  1047 PLYGEIVWAKFNn-FRWWPAIILPPTEVPsnILKKAHGe-NDFVVRFF------GTHDHGWISRRRVYLYIEGDTGDGHK 1118
gi 94707310   205 FYSGDLVWAKSGrnEPFWPAIVIDPMTQAp-ELVLRSCipDAACVVFFghsgneNERDYAWVRRGMIFPFVDYVARFQEQ 283
gi 75264636   187 FTVGDLVWAKCGkrFPAWPAVVIDPISQAp-DGVLKHCvpGAICVMFFgyskdgTQRDYAWVRQGMVYPFTEFMDKFQDQ 265
                          90       100
                  ....*....|....*....|....*
Feature 1                                  
2DAQ_A         81 qts---inKTFKKALEEAAKRFQEL 102
gi 156390320  265 nnk--ylaKVFKKALVEAKEKYDEW 287
gi 118101388  979 qts---inKTFKKALEEAAKRFQEL 1000
gi 156542877  875 gsk--kveESYRKALQEAKLFHERL 897
gi 157126101 1105 kkt--tlaKRYGLALEEAKTVHGML 1127
gi 115435314  350 tlyk-ikaSRFREAIEEAFLAERGL 373
gi 86278478   947 qtg---igKVFKNALLDAETRFKEI 968
gi 91090902  1301 vkk--rvdNAFVKAIEEAAAAHELK 1323
gi 115936704  111 ansk-rlaAVFSLALKEASQKYKLW 134
gi 158296343  657 sqsgssmdKRYRSAMTEASKIFKIL 681
gi 29427833  1119 tks--qlfRNYTTGVEEASRFLPII 1141
gi 94707310   284 pelqgckpGNFQMALEEAFLADQGF 308
gi 75264636   266 tnlfnykaSEFNKALEEAVLAENGN 290

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