Conserved Protein Domain Family
BR140_related

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cd05839: BR140_related 
The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, BR140 is disrupted by chromosomal translocations, similar to translocations of WHSC1 in lymphoid multiple myeloma. The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins seem to be nuclear, often DNA-binding proteins, that function as transcription factors regulating a variety of developmental processes.
Statistics
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PSSM-Id: 99900
View PSSM: cd05839
Aligned: 7 rows
Threshold Bit Score: 156.513
Threshold Setting Gi: 71023893
Created: 27-Nov-2007
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative
Feature 1:putative chromatin binding site
Evidence:
  • Comment:Based on sequence similarity to other PWWP proteins.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                   #  #  #                                               #   # #         
gi 156542480  862 LTALQLVWAKCRGYPWYPALIIDPNTPrgtvhkgvpi-----psppddvlaLASNYKDRVYLVLFFDtKRTWQWLPGEKL 936
gi 118102292 1043 LEPLELVWAKCRGYPSYPALIIDPKMPregllhngvpipvppmdvlklgeqRQTEAGEKLFLVLFFDnKRTWQWLPRDKV 1122
gi 116241271 1083 LDALDLVWAKCRGYPSYPALIIDPKMPregmfhhgvpipvpplevlklgeqMTQEAREHLYLVLFFDnKRTWQWLPRTKL 1162
gi 115636692 1136 LNPLDMVWAKCRGYPSYPALIIDPKMPrsgtfhngvp----ipvpttevlnQRLNLDDLLYLVLFFDnKRTWQWLPRTKL 1211
gi 125823160  464 PEPLDLVWAKSRGYPSYPALIIDPDMPqdgllhngvpipvppldvlrlgeqRQEEAGERLFLVLFFDnKRTWQWLSKDKV 543
gi 134113070  990 YPPGTLVWAKIHTFPFFPAEIVDLIDDrdevpdavl-------keetasraAAKNVNKDVWLVRFFDaRSSYGWITGDRL 1062
gi 71023893  1130 PAAGTKVWAKVETFPHFPAIVIRDKTDlpg------------------emlRTQPEDESMVAVRFFGkQTSYGWITPLKL 1191
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
Feature 1                                                      
gi 156542480  937 EPLGVsqelddg---------kliesrKPTDRKAVKKAYQDALLY 972
gi 118102292 1123 YPLGVddtvdkl---------kmmegrKTSIRKSVQVAYDRAMIH 1158
gi 116241271 1163 VPLGVnqdldke---------kmlegrKSNIRKSVQIAYHRALQH 1198
gi 115636692 1212 EPLGVdsgldnv---------klmegrKSTVRKNVQIAYDRAVHH 1247
gi 125823160  544 IPLGVddttdkl---------rimegkKTSIRKSVQVAYDRAMKH 579
gi 134113070 1063 DELGEdenvdamylagkdregkskgfkTPSLKRACRKGYRDALNS 1107
gi 71023893  1192 APLLMdesedek---------ylklaaKKGKTKQVRDAYEDAKSY 1227

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