Conserved Protein Domain Family
SPBC215_ISWI_like

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cd05840: SPBC215_ISWI_like 
Click on image for an interactive view with Cn3D
The PWWP domain is a component of the S. pombe hypothetical protein SPBC215, as well as ISWI complex protein 4. The ISWI (imitation switch) proteins are ATPases responsible for chromatin remodeling in eukaryotes, and SPBC215 is proposed to also bind chromatin. The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins seem to be nuclear, often DNA-binding, proteins that function as transcription factors regulating a variety of developmental processes.
Statistics
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PSSM-Id: 99901
View PSSM: cd05840
Aligned: 16 rows
Threshold Bit Score: 116.263
Threshold Setting Gi: 145614654
Created: 28-Nov-2007
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
putative
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:putative chromatin binding site
Evidence:
  • Comment:Based on sequence similarity to other PWWP proteins.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                  #  #  #                                                 #  # #        
1H3Z_A         7 YKPGMRVLTKMSGFPWWPSMVVTeskmtsvark--------------------skpkragtfYPVIFFPNKEYLWTGSDS 66
gi 68471081    4 YQPTSIVLAKVKGYPAWPAMVLDesllpehisnkkpksktnpptsissptpqspskkkpsiiVPVRFFSDDTYIWINTND 83
gi 50304119    6 LVTGDLVLCTVGSYEPWPAVVVPqrilsksvl----------------------kakenvgqVAVAFFNDSTYYWTKPKQ 63
gi 45190343    6 IRTGDRVLCKVGDFPPWPAVVVPqrflsklvy----------------------sgkrsksyVCVAFFNDDSYYWKEPRH 63
gi 50547799  188 FPPGTIVLAKVKGFPAWPGMVVPedvlpssvln--------------------akprknrqmWPVRFFIDTTHTWAYRND 247
gi 74644949    5 IRTGDLVLCKVGSFPPWPAVVFPqrllrndv-----------------------yrkrksncVAVCFFNDPTYYWEQPSR 61
gi 74582204   50 LNFGDRILVKAPGYPWWPALLLRrketkdsln----------------------tnssfnvlYKVLFFPDFNFAWVKRNS 107
gi 71022201   20 FQVDDVVLAKVRGFPAWPGIVMAdenvpsavlk-------------------erpvakhrdlYTIRFFPAADYHWAFSKD 80
gi 58271686   34 FDIGDIVLARLRGYPPWPARIANpetlprnvlk--------------------trpgknpnlYCCQFFPAGDFSWLQNKD 93
gi 119195621 147 AQPGEYYFARLRSWPPWPAIICDeemlpqsllatrpittkqs-dgtytehfkdgakrvhertFPVMFLHTNEFAWIPNTD 225
                         90       100       110
                 ....*....|....*....|....*....|....*.
Feature 1                                            
1H3Z_A        67 LTPLTsEAISQFLEKPk---pKTASLIKAYKMAQST 99
gi 68471081   84 LKPLTkQMIQDYFSTSskkrkIDNLLQTAYELANDP 119
gi 50304119   64 LKLLTeENIEAWIKSPpk--rSSKELKKAYQFASDY 97
gi 45190343   64 LTLLTdKMCTDWMKNSk---sKDEALIGAYQQAIEY 96
gi 50547799  248 LKPLGvEEAANFLKSAsr-grKDKSLHAAYKVASEP 282
gi 74644949   62 LKELDqDSIHNFILEHsk-naNQRELVNAYKEAKNF 96
gi 74582204  108 VKPLLdSEIAKFLGSSk---rKSKELIEAYEASKTP 140
gi 71022201   81 LELLNkDKIDSFLAGPn---rKKGDLRQAYEIARDP 113
gi 58271686   94 IKALSaSDISSFLAQPhr--kSSGGLREAYQTAQDP 127
gi 119195621 226 LVPLD-PEQCKNPEKA-----KGKGLLAAYQVASEG 255

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