Conserved Protein Domain Family
BS69_related

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cd05841: BS69_related 
The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND domains. The specific role of the PWWP domain within BS69 is not clearly identified, but BS69 functions in chromatin remodeling, consistent with other PWWP-containing proteins. The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins seem to be nuclear, often DNA-binding, proteins that function as transcription factors regulating a variety of developmental processes.
Statistics
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PSSM-Id: 99902
View PSSM: cd05841
Aligned: 12 rows
Threshold Bit Score: 140.231
Threshold Setting Gi: 45552014
Created: 16-Jan-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative
Feature 1:putative chromatin binding site
Evidence:
  • Comment:Based on sequence similarity to other PWWP proteins.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                         #  #  #                  #   # #                                
gi 10719919   232 WFCYPCIPNHELVWAKMKGFGFWPAKVMQked---nqVDVRFFGhHHQRAWIPSENIQDITvni--hrlHVKRSMGWKKA 306
gi 156717862  272 WFCYPCIPNHELVWAKMKGFGFWPAKVMQked---nqVDVRFFGhHHQRAWIPSDNIQEITvnv--hqlHVKRSMGWKKA 346
gi 25453223   269 WFCEPCSNPHPLVWAKLKGFPFWPAKALRdkd---gqVDARFFG-QHDRAWVPINNCYLMSkei--pfsVKKTKSIFNSA 342
gi 45552014   530 WFVKVCRHPHLLLWAKLKGFPYWPAKAMGssn--stlVNVRFFG-KHDRAFVPVKDCFLYSaqnpntqtSRRSARDLAEC 606
gi 50732273   272 WFCYPCIPNHELVWAKMKGFGFWPAKVMQked---nqVDVRFFGhHHQRAWIPSENIQDITvni--hrlHVKRSMGWKKA 346
gi 66548728   281 WFCIPCNPPHQLVYAKQKGYPYWPAKVMQvng---niYDVRFFGgHHMRANIEKMFIRPITtsl--qslQIKRSTAWNRA 355
gi 115640582   21 WFSEVCTKPHPLVWAKLHGFPFWPAKAMKeed---glLEARFFG-QHDRAMIPVHNCFQYStkip-fpaSKKRLTGLNSS 95
gi 117606171  291 WFCYPCSPNHELVWARMKGFGYWPAKVMQreg---nqVDVRFFGhQHQRAWIPSDNIQDITvsv--qqlQVKRSSGWKKA 365
gi 118100625  377 WFCEPCSNPHPLVWAKLKGFPFWPAKALRdkd---gqVDARFFG-QHDRAWVPINNCYLMSkei--pfsVKKTKSIFNSA 450
gi 118782130  290 WFARPCRTRHELVFAKQSRFQYWPAKVVRvvn---nlYDVRFFGgNHPRALIDAGWVKPIDtelg-tlgVKDKHGGFQLA 365
gi 7303438    366 WFAKPCLQRHELVFAKQVGSPPWPAKVMSvskrqpikYDVRFFGgTHSRALISERDITPIEsdiq-shiKPRNSRALSAA 444
gi 157111055  265 WFARPCNTRHELVFAKHKGYQYWPAKVIRvvn---nkYDVRFFGdKHSRAVVDTAFVKPIDsdlv-qlkINPKKPGFQKS 340

                  ....*..
Feature 1                
gi 10719919   307 CDELELH 313
gi 156717862  347 CDELDLH 353
gi 25453223   343 MQEMEVY 349
gi 45552014   607 IREVEIH 613
gi 50732273   347 CDELELH 353
gi 66548728   356 FDELKHH 362
gi 115640582   96 IKEAELH 102
gi 117606171  366 CDELELH 372
gi 118100625  451 MQEMEVY 457
gi 118782130  366 MKEMLKY 372
gi 7303438    445 IKELQCH 451
gi 157111055  341 MEELHKH 347

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