Conserved Protein Domain Family
GT1_like_7

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cd05844: GT1_like_7 
Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.
Statistics
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PSSM-Id: 100003
View PSSM: cd05844
Aligned: 23 rows
Threshold Bit Score: 349.246
Threshold Setting Gi: 152963989
Created: 22-Feb-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative
Feature 1:putative ADP-binding pocket [chemical binding site]
Evidence:
  • Comment:Some of the residues involved in ADP binding bind indirectly.
  • Comment:Based on similarity to sequences with known structure

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                   #                                                    
gi 161784900   3 EIVLFRQNLFrv-sEVFITQQAQALrRHVPLYTGRLRYGaGPSGARALllrdl-----------wrhmaWPRIAAQMLTR 70
gi 161787611   3 TVLVYRDRLLppseQAFMRRQYMGFrTLRPCWVGCRRDApAPDLPGDVrflgg-----------sgplrPLRQMAFRQFG 71
gi 126659442   4 PLAICAPNLGai-sETFIQRHMEELlPNKVVIVANNNKKpYCGYWTVDapslvinn-----ievtglklGLKNYLARKLF 77
gi 87301034   10 RIAIFIPLRNav-sETFIRNHVDYLpYTTIPRHGTELGItDEKGTPIWrganl-----------vgriiARLSPSLRDQL 77
gi 78183786    5 RVLVLAPTRRaa-sETFVRANLAGL-PFATTAYFGDERPlGQPWRLVYgvavl------------mskvLTRLGWLRLAG 70
gi 124024252   4 RLLVFAPTRRap-tETFVRANLQGL-PFEIIAYFGDEQPlSDPGRLAYglail------------vskaLTRLGLLRLAT 69
gi 114762861   2 KTCIATSDFFvp-gETFINRHIEHIfGGETCVLTGRFNGtDPLGKPIFerraplstadrlrapfamgwnALTESTGRLPF 80
gi 78211724    4 RVLVLAPTRRar-tETFVRANLARLpFAVEACFGDEMPWrEPLKALYGlavl-------------tskvCTRLGWLRLAT 69
gi 33864713  362 RVLVLVPTRRsp-tETFVRANLARMpLDQIVYVGDEWGGwNHPGQMAYglaia------------vskaMTRLGWHRLAS 428
gi 145594610   9 HVVIWRSHLLpg-sETFIRNQADALtTWRPSYLGAVRVPsALSRDTDTvay---------------gsaRRDRRDLLALK 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 161784900  71 DSAPylrl-------lagHAPALVHAHFGvDGVYALPLARRlgvPLVTTFHGFDVTLStarylaspawmnyplhRRALAR 143
gi 161787611  72 WGAArev---------adLAPVLVHAQFGrGGALALPIARAlgvPLVVTFHGGDAFKDrhyaggfp-psvfqrrWQALQS 141
gi 126659442  78 KQSNqesinlaiqnffqdHQVQVILGEYLnYTFSYFKIAQKldiPYFAHAHGADVSIYlrqe--------kwrkRYKQYQ 149
gi 87301034   78 RDFLlsrh-------lrsLGVTAVLAEYGvTGCWLISACKRaqiPLVVHFHGFDAYVRdvitq-------yhqsYQDLFR 143
gi 78183786   71 WPAAvvtkl-----llrrHQPDLVLVEFGfHALRVMEAAAEcqiPLVVHFRGSDLSAWtkfga-------qkmrYRRLMR 138
gi 124024252  70 LPGSlvawc-----lirrHQPDVLMTEFGfHAVRVMEAAAWsdtPLIVHFRGSDASAQnrlgl-------lkdrYRRLMV 137
gi 114762861  81 GDNKarlrd-----wlraQEVEVILAEFGtQALVVAKLAQEmdlPCFTYFRGTDASFAlrsnk-------tvraYKHMMP 148
gi 78211724   70 LPTSivaml-----lvkrHRPDVVMVEFGfHAVRVMELARLg-vPLAVHFRGADASAErylkr-------leprYRRLFQ 136
gi 33864713  429 WPAAcvafl-----liqrHRADVVLAEFGfHAVRVMDACAWsdvPLVVHFRGSDASAHrrltl-------lrerYRRLMR 496
gi 145594610  73 VSGRsprlt----hllrqLRPALVHAHFGgDGWLISRTTAElgiPLVITVHGQDVTRQpalpglr--garqrrnLRAAFD 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                            ###                         
gi 161784900 144 QGQLFLCNSGFLRDRALAlgFPADRTRVHYIGVDCTLVrprdpgEETPTILHVARLVeFKGTEYLLRAFARLapr----- 218
gi 161787611 142 HAALFVCVSEGVRDRLLErgVPARLLEVIPIGAEPAPLa----aGPADRFVFAGRFVdKKGVPVLIDAVRILagr----- 212
gi 126659442 150 QAAGIITMNKISRKRLIDlgIEEHKIHVIPYGVDTPNEaikrqkNELIRCLAVGRMVgKKAPILLLESFRRAtkn----- 224
gi 87301034  144 SAAAIIVVSHAMREKLISlgATEEKLFLNPYGVNELLFesarpaNQPARFLAVGRFVeKKAPYLTILAFHYVlqn----- 218
gi 78183786  139 IASGAIVKSQPMRQTLLDlgMESERILISASGANAQLFhssapgSAPPVFLAVGRFVdKKGPLYTIRAFAQLvgqh---p 215
gi 124024252 138 IVSGIIVKSQPMRRTLLAlgAPNDHLIVSPSGADERLFhgadpgRSSPLLVAVGRFVaKKGPLQTIRAFAAMrqslpepv 217
gi 114762861 149 RLAGVFSVSQFLLDNLARhgVSHPNAHVVPSGVDIRRFtp--aeKTPGSFLAVGRMVeKKAPQVTLRAFASAarg----- 221
gi 78211724  137 LTSAVIVKNQTMRSRLISlgAQPAQLVISPSGADEQRFqgatpaSMPPRFLAVGRFVaKKGPLDTLEAFALLqgltd--h 214
gi 33864713  497 LSSALLAKSQVMKDVLVGlgADPTAVTITPSGADETVFhaddpaRQPPHVLFVGRLIeKKGPLDALEAFAQArllvserl 576
gi 145594610 147 RAALVVAVSGFIRDRAVSlgADPAKVHVHHIGVPIPPPpa--atRREWDVAFVGRLVaKKGVDDLVEALGLLrp------ 218
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                 #                            #         
gi 161784900 219 hgtARLVIIGDGPLRSRLEALARaldiGTRVSFLGAQpHPVVMDWMrrAAMLVLPSILta-sGRVEGLGMVLLEAAATGV 297
gi 161787611 213 gvtPPVVLAGDGPLLPAMRDRAAg---LANLRFAGWLgAADLAAEMdrAIALLVPSVVpp-gGDREGLPSVAVEAMARGV 288
gi 126659442 225 ypnLQLDYVGTGDLLPAVQQFIRafqlEDKVILHGKQpNEFVLQLMkkADIFLQHSIVdpdsGDEEGLPVAILEAMGYCL 304
gi 87301034  219 vpeASLILIGEGPLLGPCKRLAQslglSGSVKFPGSRpPEYVAAQIkkSRAFVQHSLEad-nGDCEGIPVAVIEAQMSGI 297
gi 78183786  216 rtdLALWMVGEGPLQQQAEALVRelglESVVRFWGAQpQQKVAELMreVRGFVQHSVVap-dGDSEGNPVAVMEAQLSGL 294
gi 124024252 218 alsTKLVMLGDGPLLAEARQLVEalalGSAVILPGLAdRQRVAELLrqARCFVQHSQVap-dGDREGSPVAVMEAQLSGL 296
gi 114762861 222 -rdAHLTFIGDGPLLETCKAMATelgvGPQVTFTGALpHDEVRQHLmgTEIFLQHSVTak-nGNTEGLPTAIQEALACGC 299
gi 78211724  215 adaCSLVMVGDGPLLSVVQDRAHqlglEHLVQFPGVLsPDAVVQEMrrARVFVQHSRTae-dGDEEGCPVSVMEAQLCGL 293
gi 33864713  577 raeMRLRVVGDGPLQQAMQRRINelglQGCVDVLGVQpPAAVAEWMrqSRCLLLPSRIas-dGDAEGCPVAVLEAQLSGL 655
gi 145594610 219 -rrPRALFIGDGPLAAPLRTRAAe--lGLNATFCGSQpPAVVRRHLaaARLLAAPSRTap-dGDSEGLPTTILEAASAGL 294
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
Feature 1                                                                                
gi 161784900 298 PVIGSRVGGIPEGIAEGRSGLITPPRDVDALAAAIGTLLADPalrATMGGQARAFVTRQFDLRRQTEILEGY 369
gi 161787611 289 PVVASSQSGLEGAVGHAGAGIVVPAGDPMALADAMQAMLVPRt-rDAMAGAAAATARESFCAPVQSARLEAR 359
gi 126659442 305 PVISTRHAGIPESVLEGETGLLVDEGNVKEMAQNILALAQDFdlrQQMGLAGWQRVKECFSWEKEKKQLLEV 376
gi 87301034  298 PVIATKHAGIPDVVVDGSTGFLVEESDVKGMADAMIRIAKNPdlaGKMGIAARQRALSNYSLDRHINELAKI 369
gi 78183786  295 PVVATRHAGIPEVVRHGESGWLVAEADVVGMAAGLLRLVEDPglaQRWGQAGRRRIQERFTIDHHLRDVAQF 366
gi 124024252 297 PVVATRHEGIPEVVEDGVSGFLVDEGDLQGMAAAMARLIVEPdlaARLGAAGKRRAAANFTARHHLEQIAAL 368
gi 114762861 300 ITLSTIHAGIPEAVEDGVNGLLVPEWDEDGFAARIAQLLDMEd-rSAMTRAARDTAVARFDNAVLLEKVERI 370
gi 78211724  294 PVVATRHGGIPDVVVDQQTGRLVEEGDRWGMAEAMALLADRPglaAAWGAAGQRRTQARFTVKHHVDQITML 365
gi 33864713  656 PVVSTRHAGIPEVVLDGTTGLLVEEGDVAGLAQALALMCRDPqraKLLGSAGRARVMSHFTVDHHVKTVADV 727
gi 145594610 295 PVVATYHSGIPEAVVHGTTGLLGAEGDRVALAANIGRLLDNDtlrEQLGQAGRRHVVEHFDLRRQTQRLEQL 366

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