Conserved Protein Domain Family
Ig2_L1-CAM_like

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cd05845: Ig2_L1-CAM_like 
Second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM) and similar proteins
Ig2_L1-CAM_like: domain similar to the second immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM). L1 belongs to the L1 subfamily of cell adhesion molecules (CAMs) and is comprised of an extracellular region having six Ig-like domains, five fibronectin type III domains, a transmembrane region and an intracellular domain. L1 is primarily expressed in the nervous system and is involved in its development and function. L1 is associated with an X-linked recessive disorder, X-linked hydrocephalus, MASA syndrome, or spastic paraplegia type 1, that involves abnormalities of axonal growth.
Statistics
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PSSM-Id: 143253
View PSSM: cd05845
Aligned: 5 rows
Threshold Bit Score: 185.044
Threshold Setting Gi: 1705571
Created: 11-Jan-2008
Updated: 18-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1171701    130 NTPQWPKEKVTPVEVEEGdpVVLPCDPPesavPPKIYWLNSDIVHIaQDERVSMGqdGNLYFSNAmvgDSHPDYICHAHF 209
gi 1705571    134 GAPKWPKETVKPVEVEEGesVVLPCNPPpsaePLRIYWMNSKILHIkQDERVTMGqnGNLYFANVltsDNHSDYICHAHF 213
gi 118097056  130 SVPKFPKEKIEPLDVEHGdsVILHCNPPkgipPLHIYWMNIDLQHIpQDERVSMSlkGDLYFANVeenDSRSDYCCFAAF 209
gi 209969742  111 STPKWQKEMIRPIEVEEGssLILPCNPPksavPPRVIWMNSSLLHItQDKRVSMGvnGNLYFSNVqkqDEHPDYICHAQF 190
gi 229462991  129 SVPKFPKEKIDPLEVEEGdpIVLPCNPPkglpPLHIYWMNIELEHIeQDERVYMSqkGDLYFANVeekDSRNDYCCFAAF 208
                          90
                  ....*....|....*
gi 1171701    210 lgpRTIIQKEPLDLR 224
gi 1705571    214 pgtRTIIQKEPIDLR 228
gi 118097056  210 pklRTIVQKMPMTLK 224
gi 209969742  191 vgaRTIVQKEAISIK 205
gi 229462991  209 prlRTIVQKMPMKLT 223
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