1O0V,1O0V


Conserved Protein Domain Family
IgC_CH2_IgE

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cd05847: IgC_CH2_IgE 
Click on image for an interactive view with Cn3D
CH2 domain (second constant Ig domain of the heavy chain) in immunoglobulin E (IgE)
IgC_CH2_IgE: The second constant domain of the heavy chain of immunoglobulin E (IgE). The basic structure of immunoglobulin (Ig) molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda; each composed of a constant domain and a variable domain. There are five types of heavy chains: alpha, delta, epsilon, gamma, and mu, all consisting of a variable domain (VH) and three (in alpha, delta, and gamma) or four (in epsilon and mu) constant domains (CH1 to CH4). The different classes of antibodies vary in their heavy chains; the IgE class has the epsilon type. This domain (Cepsilon2) of IgE is in place of the flexible hinge region found in IgG.
Statistics
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PSSM-Id: 143255
View PSSM: cd05847
Aligned: 10 rows
Threshold Bit Score: 132.529
Threshold Setting Gi: 104089
Created: 21-Dec-2007
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
IgC dimer
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:IgC dimer interface [polypeptide binding site]
Evidence:
  • Structure:1O0V; human IgE-Fc chains A and B, C epsilon 2A/C epsilon 2B interface, based on 3.5 A distance.
    View structure with Cn3D
  • Comment:Human IgE-Fc is a disulfide-linked dimer of 3 domains: C epsilon 2- C epsilon 3- C epsilon 4.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         ####             #                                                             
1O0V_A        13 VKILQSScdggghfpptIQLLCLVSGYTPgTIQITWLEDGqvm-dvdLSTASTTQEge-lASTQSELTLSQKHWLSDrTY 90
1O0V_B        13 VKILQSScdggghfpptIQLLCLVSGYTPgTIQITWLEDGqvm-dvdLSTASTTQEge-lASTQSELTLSQKHWLSDrTY 90
gi 62183976  108 VKLFHSScnplgdthttIQLLCLISGYVPgDMEVIWLVDGqkatnmfPYTAPGTQEgn-vTSTHSELNITQGEWVSQkTY 186
gi 63524     180 VQVLHPSsctps-qsesVELLCLVTGFSPaSAEVEWLVDGvgg-llvASQSPAVRSgs-tYSLSSRVNVSGTDWREGkSY 256
gi 147906683 255 VEILQGPcas----sesVELLCLITGYAPsEIKVQWLLNGqvteispSNSKPCKEEnd-tFSSRSKVSVPKEDWNSGdSY 329
gi 345642    252 VQVLHSSvcstl-gddsVELLCVITGFSPpPVEVEWLVDGapahlvaTMTRPQREAgsktYMATSQTNVSREDWKAGkAF 330
gi 111493887 110 VRLLHSScnrns-ddatIQLVCLISGFYPsTVTVNWLVDGqsgmlpaHTEDPKKDAsgdtFSTTSTANITQLEWKEGkTY 188
gi 345580    113 VQVLQSScadtd-gngsIELVCLISGYTPdNIQVRWLVNDkmapiqgQTSPPQKDGqg-tFSTTSQINVTKSDWASGdKY 190
gi 481559    235 VFIFPPKpkdvl-trstIQLYCFIYGHILnDVSVSWLMDDreitdtlAQTVLIKEEgk-lASTCSKLNITEQQWMSEsTF 312
gi 104089    242 VEILQGPcas----sksVELLCLITGYAPsEIKVHWLLNGqvtnispSNSKPCKEEng-tFSSRSKVSVPKEDWNSEdSY 316
                         90
                 ....*....|....*...
Feature 1                       ###
1O0V_A        91 TCQVTYqgh--tfEDSTK 106
1O0V_B        91 TCQVTYqgh--tfEDSTK 106
gi 62183976  187 TCQVVYqgl--tfNANAR 202
gi 63524     257 SCRVRHpatntvvEDHVK 274
gi 147906683 330 TCKVTHpashtktEASTK 347
gi 345642    331 TCRVKHpatggtaQGHAR 348
gi 111493887 189 TCQVIHqgs--tvERNAT 204
gi 345580    191 TCKVEHpatssraEDTIH 208
gi 481559    313 TCKVTSqgv--dyLAHTR 328
gi 104089    317 TCKVTHpashtktEASTK 334

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