1CS6,2OM5


Conserved Protein Domain Family
Ig1_Contactin-2

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cd05850: Ig1_Contactin-2 
Click on image for an interactive view with Cn3D
First immunoglobulin (Ig) domain of contactin-2
Ig1_Contactin-2: First Ig domain of the neural cell adhesion molecule contactin-2-like. Contactins are comprised of six Ig domains followed by four fibronectin type III (FnIII) domains anchored to the membrane by glycosylphosphatidylinositol. Contactin-2 (TAG-1, axonin-1) facilitates cell adhesion by homophilic binding between molecules in apposed membranes. It may play a part in the neuronal processes of neurite outgrowth, axon guidance and fasciculation, and neuronal migration. The first four Ig domains form the intermolecular binding fragment, which arranges as a compact U-shaped module by contacts between IG domains 1 and 4, and domains 2 and 3. The different contactins show different expression patterns in the central nervous system. During development and in adulthood, contactin-2 is transiently expressed in subsets of central and peripheral neurons. Contactin-2 is also expressed in retinal amacrine cells in the developing chick retina, corresponding to the period of formation and maturation of AC processes.
Statistics
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PSSM-Id: 143258
View PSSM: cd05850
Aligned: 3 rows
Threshold Bit Score: 194.384
Threshold Setting Gi: 18858449
Created: 11-Jan-2008
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
interdomain
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:interdomain interface [polypeptide binding site]
Evidence:
  • Structure:1CS6_A; Gallus gallus axonin-1 Ig1/Ig4 interdomain interface, contacts based on 3.5 A distance.
    View structure with Cn3D
  • Comment:Chicken axonin-1 domains Ig1 and Ig4 interact with each other, helping to form the U shaped structure of the intermolecular binding fragment.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        ##                                                                              
1CS6_A         4 GPVFEEQPAHTLFPEgsaEEKVTLTCRARAnPPATYRWKMngtelkmgpdsRYRLvaGDLVISNPvkakDAGSYQCVATN 83
2OM5_A         3 GPVFEDQPLSVLFPEestEEQVLLACRARAsPPATYRWKMngtemklepgsRHQLvgGNLVIMNPtkaqDAGVYQCLASN 82
gi 18858449   33 GPVFEEQPSSLIYPEgmpEGKVTLGCQARSsPAAVYRWRVngtdisfaeesHYTQvaGNLVINNPqngrDGGSYQCLAIN 112
                         90
                 ....*....|....
Feature 1          ####        
1CS6_A        84 arGTVVSREASLRF 97
2OM5_A        83 pvGTVVSREAILRF 96
gi 18858449  113 rcGTIVSRVANLKF 126

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