Conserved Protein Domain Family
Ig3_Contactin-1

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cd05851: Ig3_Contactin-1 
Third immunoglobulin (Ig) domain of contactin-1
Ig3_Contactin-1: Third Ig domain of the neural cell adhesion molecule contactin-1. Contactins are comprised of six Ig domains followed by four fibronectin type III (FnIII) domains anchored to the membrane by glycosylphosphatidylinositol. Contactin-1 is differentially expressed in tumor tissues and may through a RhoA mechanism, facilitate invasion and metastasis of human lung adenocarcinoma.
Statistics
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PSSM-Id: 143259
View PSSM: cd05851
Aligned: 3 rows
Threshold Bit Score: 192.929
Threshold Setting Gi: 148223930
Created: 11-Jan-2008
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
interdomaindimerization
Feature 1:interdomain interface [polypeptide binding site]
Evidence:
  • Comment:Based on similarity to chicken axonin-1.
  • Comment:Chicken axonin-1 domains Ig2 and Ig3 interact with each other, helping to form a U-shaped axonin structure.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                              # ##### #                                                  
gi 2497301    241 PADIVVQFKDVYAlmgqNVTLECFALGNPVPDIRWRKVLEPMPSTAeistsgAVLKIFniqlEDEGIYECEAENirgKDK 320
gi 148223930  227 TPVINVKFKDTRAlkdqNVTLECFALGNPVPVITWRKINEAMPASAeismsgAVLKIFniqpEDEGTYECEAKNikgLDT 306
gi 116917     232 PADIKVKFKDTYAllgqNVTLECFALGNPVPELRWSKYLEPMPATAeismsgAVLKIFniqyEDEGLYECEAENykgKDK 311

                  ....*...
Feature 1                 
gi 2497301    321 HQARIYVQ 328
gi 148223930  307 HRAYVYVE 314
gi 116917     312 HQARVYVQ 319

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