1HCF


Conserved Protein Domain Family
Ig_TrkB_d5

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cd05855: Ig_TrkB_d5 
Click on image for an interactive view with Cn3D
Fifth domain (immunoglobulin-like) of Trk receptor TrkB
TrkB_d5: the fifth domain of Trk receptor TrkB, an immunoglobulin (Ig)-like domain which binds to neurotrophin. The Trk family of receptors are tyrosine kinase receptors, which mediate the trophic effects of the neurotrophin Nerve growth factor (NGF) family. The Trks are activated by dimerization, leading to autophosphorylation of intracellular tyrosine residues, and triggering the signal transduction pathway. TrkB shares significant sequence homology and domain organization with TrkA, and TrkC. The first three domains are leucine-rich domains. The fourth and fifth domains are Ig-like domains playing a part in ligand binding. TrKB is recognized by brain-derived neurotrophic factor (BDNF) and neurotrophin (NT)-4. In some cell systems NT-3 can activate TrkA and TrkB receptors. TrKB transcripts are found throughout multiple structures of the central and peripheral nervous systems.
Statistics
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PSSM-Id: 143263
View PSSM: cd05855
Aligned: 4 rows
Threshold Bit Score: 161.545
Threshold Setting Gi: 17943177
Created: 11-Jan-2008
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
receptorinterdomain
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:receptor binding site [polypeptide binding site]
Evidence:
  • Structure:1HCF_X, human Trkb-D5 bound to neurotrophin-45, a nerve growth factor, contacts based on 3.5 A distance.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                          #               ##  #                         
1HCF_X        19 WCIPFTVKGNPKPALQWFYNGAILNEskyICTKIHvtn--htEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHF 96
gi 56270029  298 WCIPFSVRGNPKPTLQWFHEGNVLSEtdfIWSKIHetsnntiEHHGCLQLDSPTHLNNGFYTLRAENKYGRDERSISALF 377
gi 45382555  300 WCIPFTVKGNPKPTLQWFYEGAILNEseyICTKIHvin--qsEYHGCLQLDNPTHLNNGAYTLLAKNEYGEDEKRVDAHF 377
gi 169154377 351 WCIPFVVTGNPRPDLHWYHEGKPLEEqeyIRTEIHdit--ntEYHGCLKLDTPTHIHNGIYTLVASNEFGEDRGNVTAHF 428

                 .
Feature 1         
1HCF_X        97 M 97
gi 56270029  378 M 378
gi 45382555  378 M 378
gi 169154377 429 M 429

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