Conserved Protein Domain Family
Ig2_FGFRL1-like

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cd05856: Ig2_FGFRL1-like 
Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor_like-1(FGFRL1)
Ig2_FGFRL1-like: second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor_like-1(FGFRL1). FGFRL1 is comprised of a signal peptide, three extracellular Ig-like modules, a transmembrane segment, and a short intracellular domain. FGFRL1 is expressed preferentially in skeletal tissues. Similar to FGF receptors, the expressed protein interacts specifically with heparin and with FGF2. FGFRL1 does not have a protein tyrosine kinase domain at its C terminus; neither does its cytoplasmic domain appear to interact with a signaling partner. It has been suggested that FGFRL1 may not have any direct signaling function, but instead acts as a decoy receptor trapping FGFs and preventing them from binding other receptors.
Statistics
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PSSM-Id: 143264
View PSSM: cd05856
Aligned: 6 rows
Threshold Bit Score: 151.139
Threshold Setting Gi: 115768335
Created: 11-Jan-2008
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
FGF bindingligand binding
Feature 1:FGF binding site [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1          # # #                                                                         
gi 45383249  151 RRVIARPVGSSIRLKCVASGnPRPDITWLKDnkplmpheiGENKkkkWTLNLKNLKPEDSGKYTCRVFNkVGEINATYKV 230
gi 57162008  158 RRVLEQPVGSSVRLKCLASGnPTPVITWWKDqsll--dnpQQSKrpqWTLTLKNLQPQDSAKYTCHVSNaAGHINATYKV 235
gi 47077851  127 RRVIARPVGSSVRLKCVASGhPRPDITWMKDdqaltrpeaAEPRkkkWTLSLKNLRPEDSGKYTCRVSNrAGAINATYKV 206
gi 41055190  151 KRVIARPVGSSVRLKCTASGnPRPDIVWLKDsrpltpeevGEGRkkkWTLSLKNLTPEHSGKYTCHVSNrAGEINATYKV 230
gi 148225338 151 KRVIARPVGSSVRLKCIASGnPRPDITWLKDnkpltsqeiGDNKkkkWTLNLKSLKPEDSGKYTCQVYNrVGQINATYKV 230
gi 115768335 186 AQKIMKPLNSSVRLKCKASGhPRPEIVWEKDgtrmvitegRQSRq--FTLKLSHLKPGDSGTYMCIVFNkHGRINATYEV 263

                 ..
Feature 1          
gi 45383249  231 EV 232
gi 57162008  236 DV 237
gi 47077851  207 DV 208
gi 41055190  231 EV 232
gi 148225338 231 EV 232
gi 115768335 264 DV 265

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