2E9W


Conserved Protein Domain Family
Ig4_SCFR

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cd05860: Ig4_SCFR 
Click on image for an interactive view with Cn3D
Fourth immunoglobulin (Ig)-like domain of stem cell factor receptor (SCFR)
Ig4_SCFR: The fourth Immunoglobulin (Ig)-like domain in stem cell factor receptor (SCFR). SCFR is organized as an extracellular component having five IG-like domains, a transmembrane segment, and a cytoplasmic portion having protein tyrosine kinase activity. SCFR and its ligand SCF are critical for normal hematopoiesis, mast cell development, melanocytes and gametogenesis. SCF binds to the second and third Ig-like domains of SCFR. This fourth Ig-like domain participates in SCFR dimerization, which follows ligand binding. Deletion of this fourth domain abolishes the ligand-induced dimerization of SCFR and completely inhibits signal transduction.
Statistics
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PSSM-Id: 319318
View PSSM: cd05860
Aligned: 4 rows
Threshold Bit Score: 171.979
Threshold Setting Gi: 115502411
Created: 11-Jan-2008
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
dimerization
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:dimerization interface [polypeptide binding site]
Evidence:
  • Structure:2E9W_A; human SCFR KIT forms a homodimer upon binding of SCF; contacts defined using 4.0 A contacts.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                             ####  #    
2E9W_A       286 GFINIFPMINTTVFVNdGENVDLIVEYEAFPKPEHQQWIYMNRTFtdKWEDYPksenesnirYVSELHLTRLKGTEGGTY 365
gi 75570448  302 GYVNLTVLENTTISVNaGDNLVLKVYIDAYPHPDDGVWTYFNETLlnTSDHYVatkdegnnrYVSELHLIRLKGTEKGVY 381
gi 115502411 306 GFINITSVDNSTRRVRaGESLSLRVVMNAYPKPHTFSWSYSGVKLtnTTDHVItsrt-hgnsYTSELKLVRLKVSESGIY 384
gi 729904    297 GFVRLFATMNTTIDINaGQNGNLTVEYEAYPKPKEEVWMYMNETLqnSSDHYVkfktvgnnsYTSELHLTRLKGTEGGIY 376
                         90       100
                 ....*....|....*....|.
Feature 1                             
2E9W_A       366 TFLVSNSDvNAAIAFNVYVNT 386
gi 75570448  382 TFYTTNSDdDASVSFNIQVKT 402
gi 115502411 385 TFSCLNRDaTIRQTFEVHVIS 405
gi 729904    377 TFFVSNSDaSSSVTFNVYVKT 397

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