Conserved Protein Domain Family
Ig_PDGFR-alphabeta

?
cd05861: Ig_PDGFR-alphabeta 
Immunoglobulin (Ig)-like domain of platelet-derived growth factor (PDGF) receptors (R), alpha (CD140a), and beta (CD140b)
Ig_PDGFR-alphabeta: immunoglobulin (Ig)-like domain of platelet-derived growth factor (PDGF) receptors (R), alpha (CD140a), and beta (CD140b). PDGF is a potent mitogen for connective tissue cells. PDGF-stimulated processes are mediated by three different PDGFs (PDGF-A,-B, and C). PDGFRalpha binds to all three PDGFs, whereas the PDGFRbeta binds only to PDGF-B. PDGFRs alpha and beta have similar organization: an extracellular component with five Ig-like domains, a transmembrane segment, and a cytoplasmic portion having protein tyrosine kinase activity. In mice, PDGFRalpha and PDGFRbeta are essential for normal development.
Statistics
?
PSSM-Id: 143269
View PSSM: cd05861
Aligned: 4 rows
Threshold Bit Score: 141.149
Threshold Setting Gi: 82071582
Created: 11-Jan-2008
Updated: 18-Aug-2016
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 129890    228 GENITLMCIVIgneVVNFEWTYPRKesgrlvepvtdflldmpyhIRSILHIPSAeleDSGTYTCNVTESvndHQDEKAIN 307
gi 82071582  233 GEPLTVNCTVQgveLVLFSWDIPNRdivkhkpe---tvvlsattMRSCLVFPHAtvaHSGTYVCHAHEStqdQKAFASVN 309
gi 129895    231 GETIAIDCIVLdneVVDLKWTYPGKqrgvgirnv-eeskvpyqrLVYTLTLANAtteDSGEYECAVIHAtldNRVVKKTN 309
gi 129892    228 GETIVVTCAVFnneVVDLQWTYPGEvkgkgitml-eeikvpsikLVYTLTVPEAtvkDSGDYECAARQAtreVKEMKKVT 306

                 ....*
gi 129890    308 ITVVE 312
gi 82071582  310 ITVLE 314
gi 129895    310 ITVHE 314
gi 129892    307 ISVHE 311
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap