Conserved Protein Domain Family
Ig_NCAM-1

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cd05869: Ig_NCAM-1 
Immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)
Ig_NCAM-1: immunoglobulin (Ig)-like domain similar to the fourth Ig domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM). NCAM plays important roles in the development and regeneration of the central nervous system, in synaptogenesis and neural migration. NCAM mediates cell-cell and cell-substratum recognition and adhesion via homophilic (NCAM-NCAM) and heterophilic (NCAM-non-NCAM) interactions. NCAM is expressed as three major isoforms having different intracellular extensions. The extracellular portion of NCAM has five N-terminal Ig-like domains and two fibronectin type III domains. The double zipper adhesion complex model for NCAM homophilic binding involves Ig1, Ig2, and Ig3. By this model, Ig1 and Ig2 mediate dimerization of NCAM molecules situated on the same cell surface (cis interactions), and Ig3 domains mediate interactions between NCAM molecules expressed on the surface of opposing cells (trans interactions), through binding to the Ig1 and Ig2 domains. The adhesive ability of NCAM is modulated by the addition of polysialic acid chains to the fifth Ig-like domain.
Statistics
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PSSM-Id: 143277
View PSSM: cd05869
Aligned: 4 rows
Threshold Bit Score: 189.036
Threshold Setting Gi: 127855
Created: 11-Jan-2008
Updated: 18-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2851523    306 AKPKITYVENKTAMEledQITLTCEASGDPIPSITWKTStRNISNEEKTLDGRIVVRSHARVSSLTLKEIQYTDAGEYVC 385
gi 127855     301 AKPKITYVENKTAVEl-dEITLTCEASGDPIPSITWRTAvRNISSEATTLDGHIVVKEHIRMSALTLKDIQYTDAGEYFC 379
gi 18859063   300 VQPKITFLENQTASEleeQITLTCEATGDPTPNIIWSFGrRVFTENEQSLDGNVVVRSDARVSSLTLKYVQFTDAGQYLC 379
gi 119587605  306 AKPKITYVENQTAMEleeQVTLTCEASGDPIPSITWRTStRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYIC 385
                          90
                  ....*....|....*..
gi 2851523    386 TASNTIGQDSQAMYLEV 402
gi 127855     380 IASNPIGVDMQAMYFEV 396
gi 18859063   380 TARNSIGQDIQSMYLEV 396
gi 119587605  386 TASNTIGQDSQSMYLEV 402
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