Conserved Protein Domain Family
Ig_Semaphorin_classIII

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cd05871: Ig_Semaphorin_classIII 
Immunoglobulin (Ig)-like domain of class III semaphorin
Ig_Semaphorin_class III; Immunoglobulin (Ig)-like domain of class III semaphorins. Semaphorins are classified into various classes on the basis of structural features additional to the Sema domain. Class III semaphorins are a vertebrate class having a Sema domain, an Ig domain, a short basic domain, and are secreted. They have been shown to be axonal guidance cues and have a part in the regulation of the cardiovascular, immune and respiratory systems. Sema3A, the prototype member of this class III subfamily, induces growth cone collapse and is an inhibitor of axonal sprouting. In perinatal rat cortex, it acts as a chemoattractant and functions to direct the orientated extension of apical dendrites. It may play a role, prior to the development of apical dendrites, in signaling the radial migration of newborn cortical neurons towards the upper layers. Sema3A selectively inhibits vascular endothelial growth factor receptor (VEGF)-induced angiogenesis and induces microvascular permeability. This group also includes Sema3B, -C, -D, -E, -G.
Statistics
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PSSM-Id: 143279
View PSSM: cd05871
Aligned: 11 rows
Threshold Bit Score: 123.636
Threshold Setting Gi: 8134673
Created: 11-Jan-2008
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
dimer interface
Feature 1:dimer interface [polypeptide binding site]
Evidence:
  • Comment:Based on similarity to the human class IV semaphorin, SEMA4D.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                     #                                                       #           
gi 8134674    580 PEERIIYGVENSSTFLECSpksqrALVYWQFQrrneerkeei-----------rvddhiirtdQGLLLRSLqqkDSGNYL 648
gi 8134693    596 ADEKVIFGIEFNSTFLECIpksqqATIKWYIQrsgdehreel-----------kpderiikteYGLLIRSLqkkDSGMYY 664
gi 8134673    575 LLEHKVFGVEGSSAFLECEprslqARVEWTFQragvtahtqv-----------laeertertaRGLLLRRLrrrDSGVYL 643
gi 74761676   586 VAATMVYGTEHNSTFLECLpkspqAAVRWLLQrpgdegpdqv-----------ktdervlhteRGLLFRRLsrfDAGTYT 654
gi 47209642  1149 LEVKVVYGVEGNSSFLECLgrwpqAELRWTFQrtekqhqgggwsrdsremplrgdedhlvlmgRGLLLRHLqlaHSGVFT 1228
gi 8134690    585 TEEHLAYGIENNSTLLECTprslqAKVIWFVQkgretrkeev-----------ktddrvvkmdLGLLFLRLhksDAGTYF 653
gi 94732785   525 AELKTVYGVETNSTFLECVsnspqATIKWIFQpnhsqnskelv----------pgeenllhmqRGLLLQQItstNAGLYL 594
gi 118096753  551 AVEQPVFGVEKNSTFLECRarspqTAVRWLARrgegpglsev-----------rsggrvavleQGLLIRQLgreDAGTYE 619
gi 54261688   573 TAEIVQYGVRNNTTFLECIskspqASVKWLLQkdndrrkevk------------lneriiatgQGLFIRSVqetDQGVYH 640
gi 8134670    575 AAETVQYGVKNNTTFLECTpkspqASIKWLLQkdndrrkevk------------lseriiateQGLLIRSVqdsDRGLYH 642
gi 115528243  574 ISERLQIGVEGGSVFLQCDthsplESVTWLLQregsqhrr---------------evrlagidGGAVLRSVqasDAGVYT 638
                          90       100
                  ....*....|....*....|..
Feature 1                               
gi 8134674    649 CHAVEHGFiqTLLKVTLEVIDT 670
gi 8134693    665 CKAQEHTFihTIVKLTLNVIEN 686
gi 8134673    644 CAAVEQGFtqPLRRLSLHVLSA 665
gi 74761676   655 CTTLEHGFsqTVVRLALVVIVA 676
gi 47209642  1229 CTSHERSFsqALARYRLHVIAS 1250
gi 8134690    654 CQTVEHSFvhTVRKITLEVVEE 675
gi 94732785   595 CMAFEHSFsrTLARYELHVIPQ 616
gi 118096753  620 CQAVEHSFsrPLTRYSLHVIRH 641
gi 54261688   641 CVATENTFkqTITKVNLKVLEP 662
gi 8134670    643 CIATENNFkqTLAKINFKVLDT 664
gi 115528243  639 CTGTENGFrrSRGKIRLNVLPR 660

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