Conserved Protein Domain Family
Ig_Sema4B_like

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cd05872: Ig_Sema4B_like 
Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4B
Ig_Sema4B_like; Immunoglobulin (Ig)-like domain of Sema4B and similar proteins. Sema4B is a Class IV semaphorin. Semaphorins are classified based on structural features additional to the Sema domain. Sema4B has extracellular Sema and Ig domains, a transmembrane domain and a short cytoplasmic domain. Sema4B has been shown to preferentially regulate the development of the postsynaptic specialization at the glutamatergic synapses. This cytoplasmic domain includes a PDZ-binding motif upon which the synaptic localization of Sem4B is dependent. Sema4B is a ligand of CLCP1. CLCP1 was identified in an expression profiling analysis, which compared a highly metastic lung cancer subline with its low metastic parental line. Sema4B was shown to promote CLCP1 endocytosis, and their interaction is a potential target for therapeutic intervention of metastasis.
Statistics
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PSSM-Id: 143280
View PSSM: cd05872
Aligned: 8 rows
Threshold Bit Score: 106.356
Threshold Setting Gi: 8134694
Created: 11-Jan-2008
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
dimer interface
Feature 1:dimer interface [polypeptide binding site]
Evidence:
  • Comment:Based on similarity to the human class IV semaphorin, SEMA4D.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                    #                                          #                        
gi 118092972 543 LPWKNRTVLRGDDVLLPCDqrsnlARAVWLLNgsevpgtg--qerlrvgvDGLLVTNTlpgHSGEYRCYGEErGLXTLLA 620
gi 47220634  515 VTHRKRSVMAGDDVLLQCElrsnlASPRWTLNgrelmgygl-nsgyrigtDGLLIIGAraqQSGTYRCFAVEnSVSVLVF 593
gi 50415520  556 PFVKNITVGIGTNVVLPCQlssnlAQPVWTFNgqdlesdqddsvlfdttlQALVILGVgthHSGCYVCYSEEqGTQLTAE 635
gi 147907332 557 LKKKVRTVIKGNDVLLQCDlrsnlARPQWYVNgtnklyns--eghtrlgvDGLLITDTlpeHSGEYNCYSEEnGLQSLIA 634
gi 118096037 217 TPCQRIQLPPNAVQPLPCRllsnlASRRWLHNgtpvna------sylvlpEGALILVGspeRAGTYECWSLEeGFRKLMA 290
gi 48257069  287 KPCEQVQFQPNTVNTLACPllsnlATRLWLRNgapvnas----aschvlpTGDLLLVGt-qQLGEFQCWSLEeGFQQLVA 361
gi 189530083 521 AAVLFKTAHLNEIVVLPCQsksklAKMTWRFSnnslvpq----fpylqwtDGSLVFPVsleTTNTYRCVSEElGFQQTIA 596
gi 8134694   570 PVVFEVPVATAAHVVLPCSpssawASCVWHQPsgvta--------ltprrDGLEVVVTp-gAMGAYACECQEgGAAHVVA 640

                 ....*....
Feature 1                 
gi 118092972 621 AYSLTVLPQ 629
gi 47220634  594 LYSVRVHTD 602
gi 50415520  636 SYQLTVVAS 644
gi 147907332 635 AYSLNVLLE 643
gi 118096037 291 SYCVAVQEP 299
gi 48257069  362 SYCPEVVED 370
gi 189530083 597 TFSVNLPVV 605
gi 8134694   641 AYSLVWGSQ 649

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