1NEU


Conserved Protein Domain Family
Ig_P0

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cd05879: Ig_P0 
Click on image for an interactive view with Cn3D
Immunoglobulin (Ig)-like domain of Protein zero (P0)
Ig_P0ex: immunoglobulin (Ig) domain of Protein zero (P0), a myelin membrane adhesion molecule. P0 accounts for over 50% of the total protein in peripheral nervous system (PNS) myelin. P0 is a single-pass transmembrane glycoprotein with a highly basic intracellular domain and an Ig domain. The extracellular domain of P0 (P0-ED) is similar to the Ig variable domain, carrying one acceptor sequence for N-linked glycosylation. P0 plays a role in membrane adhesion in the spiral wraps of the myelin sheath. The intracellular domain is thought to mediate membrane apposition of the cytoplasmic faces and may, through electrostatic interactions, interact directly with lipid headgroups. It is thought that homophilic interactions of the P0 extracellular domain mediate membrane juxtaposition in the extracellular space of PNS myelin.
Statistics
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PSSM-Id: 143287
View PSSM: cd05879
Aligned: 4 rows
Threshold Bit Score: 227.84
Threshold Setting Gi: 157832102
Created: 11-Jan-2008
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
tetramer
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:tetramer interface [polypeptide binding site]
Evidence:
  • Comment:Tetrameric association of P0ex domains inferred from crystal contacts and supported by analytical ultracentrifugation.
  • Citation:PMID 8816707
  • Comment:P0ex tetramer is comprised of four molecules arranged around a central hole.
  • Comment:P0ex domains, may come from one membrane surface as tetramers, that link to POex tetramers from the opposing membrane surface.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        # #           #       # #                                         #  #          
1NEU_A         2 VVYTDREVYGAVGSQVTLHCSFWSSewvsddISFTWRyqpeggrdaISIFHYakgqpyidevgtfkERIQWVGDPSWKDG 81
gi 585535     31 HVYTPREVYGTVGSHVTLSCSFWSSewisedISYTWHfqaegsrdsISIFHYgkgqpyiddvgsfkERMEWVGNPRRKDG 110
gi 148223848  30 EVYTDREVYGTAGSRVTLSCSFWSSewisddISVTWHyqpdhsremYSIVHFakglssi-dagifkDRIEWVGSPKWKDA 108
gi 35902687   23 VVNTDSEKHALVGSDVRLSCSFFSWqwtspeVSFTWHyrpdgakdaISIFHYgggeaypankgpfqNRLEFVGNPSRRDG 102
                         90       100       110
                 ....*....|....*....|....*....|....*.
Feature 1            ##                              
1NEU_A        82 SIVIHNLDYSDNGTFTCDVKNPPDivGKTSQVTLYV 117
gi 585535    111 SIVIHNLDYTDNGTFTCDVKNPPDivGKSSQVTLYV 146
gi 148223848 109 SIVVHNLELTDNGTFTCDVKNPPDvvGKSSYVHLQV 144
gi 35902687  103 SILIKNLDFGDNGTFTCDAKNPPDigGHPSTIRLLV 138

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