Conserved Protein Domain Family
Ig1_Necl-2

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cd05881: Ig1_Necl-2 
First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule 2
Ig1_Necl-2: domain similar to the N-terminal immunoglobulin (Ig)-like domain of nectin-like molecule-2, Necl-2 (also known as cell adhesion molecule 1 (CADM1), SynCAM1, IGSF4A, Tslc1, sgIGSF, and RA175). Nectin-like molecules have similar domain structures to those of nectins. At least five nectin-like molecules have been identified (Necl-1 - Necl-5). They all have an extracellular region containing three Ig-like domains, a transmembrane region, and a cytoplasmic region. The N-terminal Ig-like domain of the extracellular region, belongs to the V-type subfamily of Ig domains, is essential to cell-cell adhesion, and plays a part in the interaction with the envelope glycoprotein D of various viruses. Necl-2 has Ca(2+)-independent homophilic and heterophilic cell-cell adhesion activity. Necl-2 is expressed in a wide variety of tissues, and is a putative tumour suppressor gene, which is downregulated in aggressive neuroblastoma.
Statistics
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PSSM-Id: 143289
View PSSM: cd05881
Aligned: 4 rows
Threshold Bit Score: 202.556
Threshold Setting Gi: 158538880
Created: 11-Jan-2008
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
putative dimer
Feature 1:putative dimer interface [polypeptide binding site]
Evidence:
  • Comment:Based on similarity to human CADM3 (Necl-1).

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                  #  #    ## #     # #                                  
gi 115527968  46 NLFTKDVTVIEGEVATISCQVnksDDSVIQLLNPNRQTIYFRDFRPLKDSRFQLLNFSssELKVSLTNVSISDEGRYFCQ 125
gi 148230168  30 NLVTEDVTVVEGEVAIISCRVknnDDSVIQLLNPNRQTIYFRDVRPLKDSRFQLVNFSsnELRVSLSNVTLEDEGRYLCQ 109
gi 118101955  32 NLITEDVTVVEGDVATISCRVknsDDSVIQLLNPNRQTIYFRDFRPLKDSRFQLVNFSnsELRVSLTNVSISDEGRYFCQ 111
gi 158538880  46 NLVTNNVSVVEGETAIISCRVknnDDSVIQLLNPNRQTIYFRDVRPLKDSRFQLVNFSdnELLVSLSNVSLSDEGRYVCQ 125
                         90
                 ....*....|....*
Feature 1         #             
gi 115527968 126 LYTdpPQESYTTITV 140
gi 148230168 110 LYTdpPQEAFTTITV 124
gi 118101955 112 LYTdpPQEIYTTITV 126
gi 158538880 126 LYTdpPQEAYADITV 140

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