1Z9M


Conserved Protein Domain Family
Ig1_Necl-1

?
cd05882: Ig1_Necl-1 
Click on image for an interactive view with Cn3D
First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molcule-1 (Necl-1, also known as cell adhesion molecule3 (CADM3))
Ig1_Necl-1: domain similar to the N-terminal immunoglobulin (Ig)-like domain of nectin-like molecule-1, Necl-1 (also known as celll adhesion molecule 3 (CADM3), SynCAM2, IGSF4). Nectin-like molecules have similar domain structures to those of nectins. At least five nectin-like molecules have been identified (Necl-1 - Necl-5). They all have an extracellular region containing three Ig-like domains, a transmembrane region, and a cytoplasmic region. The N-terminal Ig-like domain of the extracellular region belongs to the V-type subfamily of Ig domains, is essential to cell-cell adhesion, and plays a part in the interaction with the envelope glycoprotein D of various viruses. Necl-1 has Ca(2+)-independent homophilic and heterophilic cell-cell adhesion activity. Necl-1 is specifically expressed in neural tissue, and is important to the formation of synapses, axon bundles, and myelinated axons.
Statistics
?
PSSM-Id: 143290
View PSSM: cd05882
Aligned: 3 rows
Threshold Bit Score: 197.963
Threshold Setting Gi: 90108609
Created: 11-Jan-2008
Updated: 18-Aug-2016
Structure
?
Program:
Drawing:
Aligned Rows:
 
dimer interface
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:dimer interface [polypeptide binding site]
Evidence:
  • Structure:1Z9M_A, human CADM3 (Necl-1) N-terminal IgV domain dimer interface, contacts based on 3.5 A distance.
    View structure with Cn3D

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                  #  #    ## #     # #                                  
1Z9M_A        42 QPWTSDETVVAGGTVVLKCQVkdhEDSSLQWSNPAQQTLYFGEKRALRDNRIQLVTSTphELSISISNVALADEGEYTCS 121
gi 113675398  43 QPVTQDETVAVGGVVTLTCGVkenDNSSLQWSNTAQQTLYFGEKRALRDNRIQLVKSTatELIITIGDVQLSDDGEYTCS 122
gi 147901041  27 QPVTADVIVPTGGTAILKCTVqehLESSLQWSNTAQQTLYFGEKRALRDNRIQLVHSSpnELTISISNVVLSDEGEYTCS 106
                         90
                 ....*....|....*
Feature 1         #             
1Z9M_A       122 IFTmpVRTAKSLVTV 136
gi 113675398 123 IFTmpVRTARATVTV 137
gi 147901041 107 IFTmpVRTAKAVVTV 121

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap