Conserved Protein Domain Family
Ig2_Necl-2

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cd05883: Ig2_Necl-2 
Second immunoglobulin (Ig)-like domain of nectin-like molecule 2 (also known as cell adhesion molecule 1 (CADM1))
Ig2_Necl-2: second immunoglobulin (Ig)-like domain of nectin-like molecule 2 (also known as cell adhesion molecule 1 (CADM1)). Nectin-like molecules (Necls) have similar domain structures to those of nectins. At least five nectin-like molecules have been identified (Necl-1 - Necl-5). These have an extracellular region containing three Ig-like domains, one transmembrane region, and one cytoplasmic region. Necl-2 has Ca(2+)-independent homophilic and heterophilic cell-cell adhesion activity. Necl-1 is expressed in a wide variety of tissues, and is a putative tumour suppressor gene, which is downregulated in aggressive neuroblastoma. Ig domains are likely to participate in ligand binding and recognition.
Statistics
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PSSM-Id: 143291
View PSSM: cd05883
Aligned: 4 rows
Threshold Bit Score: 155.501
Threshold Setting Gi: 47227747
Created: 11-Jan-2008
Updated: 18-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148664211 161 EIEVNCTAMasKPATTIRWFKGNTELKgkse--veewSDMYTVTSQLMLKvhkeDDGVPVICQVEHPAVTgnLQTQRYLE 238
gi 118101955 147 EIELNCTAMasRPATTIRWFKGNKELTgkse--veqwSDMYTVTSQLLLKvgreDDGVPVICLVDHPAVKd-LQTQRYLE 223
gi 148230168 145 EVEMNCTALasKPAATIRWFKGNKELTavktdvepmeERMFRVRSQLMLTakreDDGIPIVCLVDHPAVKd-LQTQQYLE 223
gi 47227747  119 ETELTCTAIgsKPAASIRWMKGEEELTgeatv-eetyDRMFTVTSRVRFSvtkdDDGVPVDCIIDHPAAKd-LLAQRHLE 196

                 ....
gi 148664211 239 VQYK 242
gi 118101955 224 VMYK 227
gi 148230168 224 VQYA 227
gi 47227747  197 VLCE 200
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