Conserved Protein Domain Family
Ig2_Necl-3

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cd05884: Ig2_Necl-3 
Second immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3, also known as cell adhesion molecule 2 (CADM2))
Ig2_Necl-3: second immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3, also known as cell adhesion molecule 2 (CADM2)). Nectin-like molecules have similar domain structures to those of nectins. At least five nectin-like molecules have been identified (Necl-1 - Necl-5). These have an extracellular region containing three Ig-like domains, one transmembrane region, and one cytoplasmic region. Necl-3 has been shown to accumulate in tissues of the central and peripheral nervous system, where it is expressed in ependymal cells and myelinated axons. It is observed at the interface between the axon shaft and the myelin sheath. Ig domains are likely to participate in ligand binding and recognition.
Statistics
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PSSM-Id: 319320
View PSSM: cd05884
Aligned: 5 rows
Threshold Bit Score: 151.69
Threshold Setting Gi: 41054880
Created: 11-Jan-2008
Updated: 18-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82236038  141 TIQLTCKSSgsKPAADIRWFKNDqeitdvqkiqqqdsngkTFTVTSSLVFQgdrkDDGAVIRCRVDHESLTStpQIAKQV 220
gi 118083732  33 RMQLTCKTSgsKPAADIRWFKNDkevkdvkylkeedanrkTFTVSSTMDFLadrnDDGAVISCRVDHESLNStpQIAMQV 112
gi 52545789   37 LMQLTCKTSgsKPAADIRWFKNDkeikdvkylkeedanrkTFTVSSTLDFRvdrsDDGVAVICRVDHESLNAtpQVAMQV 116
gi 23267080  143 LMQLTCKTSgsKPAADIRWFKNDkeikdvkylkkedanrkTFTVSSTLDFRvdrsDDGVAVICRVDHESLNTtpQVAMQV 222
gi 41054880  156 HITLTCVTSgsKPAADVRWFKNEmevkgak---evnasgkTFTVKSSLRLHvnrdDDGVAYTCRVDHVALTAthEETTQV 232

                 ...
gi 82236038  221 LEI 223
gi 118083732 113 LEI 115
gi 52545789  117 LEI 119
gi 23267080  223 LEI 225
gi 41054880  233 LEV 235
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