Conserved Protein Domain Family
Ig2_Necl-4

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cd05885: Ig2_Necl-4 
Second immunoglobulin (Ig)-like domain of nectin-like molecule-4 (Necl-4, also known as cell adhesion molecule 4 (CADM4))
Ig2_Necl-4: second immunoglobulin (Ig)-like domain of nectin-like molecule-4 (Necl-4, also known as cell adhesion molecule 4 (CADM4)). Nectin-like molecules have similar domain structures to those of nectins. At least five nectin-like molecules have been identified (Necl-1-Necl-5). These have an extracellular region containing three Ig-like domains, one transmembrane region, and one cytoplasmic region. Ig domains are likely to participate in ligand binding and recognition. Necl-4 is expressed on Schwann cells, and plays a key part in initiating peripheral nervous system (PNS) myelination. In injured peripheral nerve cells, the mRNA signal for both Necl-4 and Necl-5 was observed to be elevated. Necl-4 participates in cell-cell adhesion and is proposed to play a role in tumor suppression.
Statistics
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PSSM-Id: 143293
View PSSM: cd05885
Aligned: 3 rows
Threshold Bit Score: 163.604
Threshold Setting Gi: 89941401
Created: 11-Jan-2008
Updated: 18-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89941401   14 EVELSCLVPrsRPAATLRWYrdrkelkgvsssqengkVWSVASTVRFRvdrkDDGGIIICEAQNQALpsghsKQTQYVLD 93
gi 148222099 143 EIELTCISPrtKPAATLRWYrdrkelkgftskqengkTFSITNSIRFNvdrkDDGNIVTCEASHPALkg-qkKQTQYELD 221
gi 55925349  142 EVELTCLSLrsKLPATLRWVrdrreipgvisqqengkTVSVSNTIRIPverkDNGAALSCEASHPALvs-qkRVRHYSLD 220

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gi 89941401   94 V 94
gi 148222099 222 V 222
gi 55925349  221 V 221
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