Conserved Protein Domain Family
Ig2_Nectin-1_like

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cd05890: Ig2_Nectin-1_like 
Second immunoglobulin (Ig) domain of nectin-1 (also known as poliovirus receptor related protein 1, or as CD111) and similar proteins
Ig2_Nectin-1_like: domain similar to the second immunoglobulin (Ig) domain of nectin-1 (also known as poliovirus receptor related protein 1, or as CD111). Nectin-1 belongs to the nectin family comprised of four transmembrane glycoproteins (nectins-1 through 4). Nectins are synaptic cell adhesion molecules (CAMs) which facilitate adhesion and signaling at various intracellular junctions. Nectins form homophilic cis-dimers, followed by homophilic and heterophilic trans-dimers involved in cell-cell adhesion. Nectins also heterophilically trans-interact with other CAMs such as nectin-like molecules (necls); nectin-1 for example, has been shown to trans-interact with necl-1. Nectins also interact with various other proteins, including the actin filament (F-actin)-binding protein, afadin. Mutation in the human nectin-1 gene is associated with cleft lip/palate ectodermal dysplasia syndrome (CLPED1). Nectin-1 is a major receptor for herpes simplex virus through interaction with the viral envelope glycoprotein D.
Statistics
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PSSM-Id: 143298
View PSSM: cd05890
Aligned: 3 rows
Threshold Bit Score: 189.816
Threshold Setting Gi: 47227897
Created: 11-Jan-2008
Updated: 18-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118101917 611 PTNRMEGTtrpliaksgrtekILVATCISSnGKPPSTVTWDtklkGEAEFQEIRNSnGTFTVISRYRLVpsreAHRQQLM 690
gi 47227897  129 PMTRMTLTtptiva-raqkrkMTVATCVSAnGKPPSVIRWDtrlkGEPTFQETRNQnGTVTVRSNYVLIpsreTHKQKLT 207
gi 18202503  146 PTNWIEGTqavlrakkgqddkVLVATCTSAnGKPPSVVSWEtrlkGEAEYQEIRNPnGTVTVISRYRLVpsreAHQQSLA 225
                         90
                 ....*....|....*...
gi 118101917 691 CVVNYQLDRFTDSITLNV 708
gi 47227897  208 CIVTYRNERITDSVVLNV 225
gi 18202503  226 CIVNYHMDRFKESLTLNV 243
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