Conserved Protein Domain Family
Ig1_IL1RAPL-1_like

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cd05896: Ig1_IL1RAPL-1_like 
First immunoglobulin (Ig)-like domain of X-linked interleukin-1 receptor accessory protein-like 1 (IL1RAPL-1)
Ig1_ IL1RAPL-1_like: domain similar to the first immunoglobulin (Ig)-like domain of X-linked interleukin-1 receptor accessory protein-like 1 (IL1RAPL-1). IL-1 alpha and IL-1 beta are cytokines which participates in the regulation of inflammation, immune responses, and hematopoiesis. These cytokines bind to the IL-1 receptor type 1 (IL1R1), which is activated on additional association with an accessory protein, IL1RAP. IL-1 also binds a second receptor designated type II (IL1R2). Mature IL1R1 consists of three Ig-like domains, a transmembrane domain, and a large cytoplasmic domain. Mature IL1R2 is organized similarly except that it has a short cytoplasmic domain. The latter does not initiate signal transduction. A naturally occurring cytokine IL-1RA (IL-1 receptor antagonist) is widely expressed and binds to IL-1 receptors, inhibiting the binding of IL-1 alpha and IL-1 beta. IL1RAPL is encoded by a gene on the X-chromosome, this gene is wholly or partially deleted in multiple cases of non-syndromic mental retardation. This group also contains IL1RAPL-2, which is also encoded by a gene on the X-chromosome and is a candidate for another non-syndromic mental retardation loci.
Statistics
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PSSM-Id: 143304
View PSSM: cd05896
Aligned: 4 rows
Threshold Bit Score: 210.557
Threshold Setting Gi: 117606157
Created: 11-Jan-2008
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
putative
Feature 1:putative antagonist binding site [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1          # ######                                                                      
gi 7321329    32 TDWSIDIKKYQVlvgePVRIKCALfygyirtnyslaqsagLSLMWYKSSGPgdfeep--iafdgsRMSKEeDSIWFrptl 109
gi 118089705  21 IDWSVDLKTYMAlagePVRVKCALfysyirtnysmaqstgLRLMWYKNKGDleepi----ifsevRMSKDeDSIWFhsvd 96
gi 118403597  32 IDWSVDLKKYMGlagePVRVKCALfysyirtnysmaqsagLRLMWYKTKGDleepi----ifsvvRMSKDdDSIWIhtae 107
gi 117606157  33 TDWSVDYLKCRVlhgePVRIKCALfygyiranytqaqsigLSLMWYRSSGLghgdfeepisfdgtRMSKEeDAIWFrpae 112
                         90       100
                 ....*....|....*....|....*.
Feature 1                                  
gi 7321329   110 lqDSGLYACVIRNSTYCMKVSISLTV 135
gi 118089705  97 lqDSGFYTCVLRNSTYCMKVSMSLTV 122
gi 118403597 108 vqDGGLYTCVLRNATYCMKVSMSLTV 133
gi 117606157 113 lqDAGLYSCVLRNSTFCMKVSMTLLV 138

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