Conserved Protein Domain Family
Ig2_IL1R2_like

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cd05897: Ig2_IL1R2_like 
Second immunoglobulin (Ig)-like domain of interleukin-1 receptor-2 (IL1R2)
Ig2_IL1R2_like: domain similar to the second immunoglobulin (Ig)-like domain of interleukin-1 receptor-2 (IL1R2). IL-1 alpha and IL-1 beta are cytokines which participate in the regulation of inflammation, immune responses, and hematopoiesis. These cytokines bind to the IL-1 receptor type 1 (IL1R1), which is activated on additional association with an accessory protein, IL1RAP. IL-1 also binds the type II (IL1R2) represented in this group. Mature IL1R2 consists of three IG-like domains, a transmembrane domain, and a short cytoplasmic domain. It lacks the large cytoplasmic domain of Mature IL1R1, and does not initiate signal transduction. A naturally occurring cytokine IL-1RA (IL-1 receptor antagonist) is widely expressed and binds to IL-1 receptors, inhibiting the binding of IL-1 alpha and IL-1 beta.
Statistics
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PSSM-Id: 143305
View PSSM: cd05897
Aligned: 5 rows
Threshold Bit Score: 163.012
Threshold Setting Gi: 62751556
Created: 11-Jan-2008
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
putative
Feature 1:putative antagonist binding site [polypeptide binding site]
Evidence:
  • Comment:Based on similarity to human IL1R.
  • Comment:The naturally occurring cytokine IL-1RA (IL-1 receptor antagonist) is widely expressed and binds to IL-1 receptors, inhibiting the binding of IL-1 alpha and IL-1 beta.
  • Citation:PMID 7867645

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                     #    # #                                  #                        
gi 124310    136 ISYPQILTLstsGVLVCPDLSEFtrdktdVKIQWYKDSLLLDKDNEkflsvrgtTHLLVHDVAleDAGYYRCVLTfaheG 215
gi 149633185 138 NSYKQILFTatsGKLVCPELRNFiskdtaLEVNWYKDSVLLDKNSEnftvvkgsPFLLIKHISlgDSGYYICEMIftqeG 217
gi 62751556  138 IAYEQLAFEhsqFQMFCPDLSDFtinrtdVQLQWYKDGKLLENDIKymys-sgtTYMHIIDIVknDGGYYTCKLQftheN 216
gi 118084304 124 IAYPQILFTftsGKIVCPNLWEFtinrtnMELQWYKDALLLEDDSEkfvflkesSSLFFTSVLptDSGYYTCKMAfpyeG 203
gi 126337273 134 ISYRQTVVSsspGRLVCPEINDFiqktnkMEIKWYKDSVLLDESNKkfsilkgsTDCHINNVSlnNSGYYTCELPfvhgN 213
                         90
                 ....*....|....*
Feature 1                       
gi 124310    216 QQYNITRSIELRIKK 230
gi 149633185 218 KKYNITRRIELQVIE 232
gi 62751556  217 KEYVVSRIIHLRIVG 231
gi 118084304 204 VTYEITRTIKLQTVE 218
gi 126337273 214 VKYNITRHIKLRVLK 228

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