1KB5,1NFD,1KTK,2EYR,1ZGL,1OGA,1BWM,1J8H,2ESV,1MI5,1FYT


Conserved Protein Domain Family
IgV_TCR_beta

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cd05899: IgV_TCR_beta 
Click on image for an interactive view with Cn3D
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) bet a chain
IgV_TCR_beta: immunoglobulin (Ig) variable domain of the beta chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta, polypeptide chains with variable (V) and constant (C) regions. This group includes the variable domain of the alpha chain of alpha/beta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens; they recognize proteins antigens directly and without antigen processing, and MHC independently of the bound peptide.
Statistics
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PSSM-Id: 143307
View PSSM: cd05899
Aligned: 22 rows
Threshold Bit Score: 127.406
Threshold Setting Gi: 71795346
Created: 26-Dec-2007
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:IgV heterodimer interface [polypeptide binding site]
Evidence:
  • Structure:1NFD_B; human alpha/beta T-cell receptor (TCR) beta chain IgV domain forms interface with alpha chain IgV domain, contacts based on 3.5 A distance.
    View structure with Cn3D
  • Comment:Human alpha/beta T cell receptor (TCR) heterodimer in complex with an anti-TCR Fab fragment.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                           # #        #  #                              
1KB5_B         4 LEQnp--rwRLVPRGQAVNLRCILKns-qYPWMSWYQQdlq-kqLQWLFTLRSpgdkevk--slpgadYLATRVtd-tEL 76
1NFD_B         4 VVQsp--rhIIKEKGGRSVLTCIPIs--gHSNVVWYQQtlg-keLKFLIQHYEkverdk---gflpsrFSVQQFdd-yHS 74
1KTK_E         4 VSQhp--srVIAKSGTSVKIECRSLdf-qATTMFWYRQfpk-qsLMLMATSAEgskatye-qgvekdkFLINHAsl-tLS 77
gi 71795346   25 VSQkpsftiLRTGEFVVSEINCSHSis-sYDRIYWYKQdes-raLKLLGYLNTniqnvee-dvkgkisFDGDGRs---GS 98
gi 124377276  24 VTQtp---lLWMMEGQSATMNCSHTkgtsYYEMYWYRQlpgqrmKEIVFTTQSpphqyes--gfstekFPATKKda-lTG 97
gi 136495     23 ITQsp---rYLILGRANKSLECEQHl--gHNAMYWYKQsae-kpPELMFLYNLkqlirn---etvpsrFIPECPds-sKL 92
gi 18147379   24 ITQwp--hyISRFPSGSAEMHCYQNdt-dYNHMYWYRQqrg-kePQLVVYLVGssanfe---egfksgFEAEIVqk-kKW 95
gi 25264852   26 VKQppv-lsVCREGDASVTLRCYHDds-sYYYMFWYRQrd--nnMEMLTYSLGqglweiqppfekdvhYTMSRPel-tRS 100
gi 12034900   20 VIQhp--diSWSFVSQQAEMNCSHKkdvgHNQMYWYRQrpg-etMSLIVYTAVglppdyg--gvsqtkYTASKEky-dYG 93
gi 1839131    17 ITQep--rsIITRAGSAALMRCEQKts-dYEWMFWYQQrdg-hgLQLISTQLRgdkptye--egykdgFQVNRTengkIS 90
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
Feature 1                      # #                ###      
1KB5_B        77 RLQVAnms--qgRTLYCTCSAApdwgasaeTLYFGSGTRLTV 116
1NFD_B        75 EMNMSaleledsAMYFCASSLRwg-----dEQYFGPGTRLTV 111
1KTK_E        78 TLTVTsahpedsSFYICSALAGsgs--stdTQYFGPGTRLTV 117
gi 71795346   99 SLSIAavglkdsGVYFCAASPKpt----ggEAYFGSGTKLTV 136
gi 124377276  98 SLTVErlllndsGVYFCAVTSGgn-----tEAHFGGGTKLTV 134
gi 136495     93 LLHISavdpedsAVYFCASSHGqgv--sgnTLYFGEGSRLIV 132
gi 18147379   96 SLKIPsiqekdeAVYLCAASRDsn----ydPAYFGSGTKLTV 133
gi 25264852  101 TLEIKnlevgdgAVYYCASSRQgs----nqPAFFGNGTKLSV 138
gi 12034900   94 ALTVKdlqpedsGVYFCAVSTGgd----ydPAYFGKGTKLTV 131
gi 1839131    91 FLEIKspkpqdqSLYLCAASDPrg----adRLYFGDGTILTV 128

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