Conserved Protein Domain Family
Ig_Versican

?
cd05901: Ig_Versican 
Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), versican
Ig_Versican: immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), versican. In CSPGs, the Ig-like domain is followed by hyaluronan (HA)-binding tandem repeats, and a C-terminal region with epidermal growth factor-like, lectin-like, and complement regulatory protein-like domains. Separating these N- and C-terminal regions is a nonhomologous glycosaminoglycan attachment region. In cartilage, the CSPG aggrecan (not included in this group) forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Like aggrecan, versican has a wide distribution in connective tissue and extracellular matrices. Aggregates having other CSPGs substituting for aggrecan may contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.
Statistics
?
PSSM-Id: 143309
View PSSM: cd05901
Aligned: 3 rows
Threshold Bit Score: 207.906
Threshold Setting Gi: 47550825
Created: 29-Jan-2008
Updated: 18-Aug-2016
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506816     36 LSGKVSLPCHFstmptlpp--syntsefLRIKWSkievdkngkDLKETTVLVAqngnikigqdykgrvSVPTHPEAVGDA 113
gi 47550825    41 LAQSVVLPCRFlvlpplpgssvithsdhLRIKWTkl------qSHGEAVAVVAqngivkmgqeymgrvSVPSRPEDQGDA 114
gi 158138921   36 LSGRVNLPCFFstiptlpp-synitnefLRIKWTkivqsrdgkDPKETTVLVAqsgsikigqhyrgrvSVPSHPEDIGDA 114
                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2506816    114 SLTVvkLLASDAGLYRCDVMYGIEDTQDTVSLTVDGVV 151
gi 47550825   115 SLTIsrLRASDAGVYRCEVMHGIEDTQDSITLDVSGVV 152
gi 158138921  115 SLTIvkLRASDAGAYRCEVLFGIEDTQDTVSLDVSGVV 152
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap