Conserved Protein Domain Family
Ig_Neurocan

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cd05902: Ig_Neurocan 
Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), neurocan
Ig_Neurocan: immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), neurocan. In CSPGs, the Ig-like domain is followed by hyaluronan (HA)-binding tandem repeats, and a C-terminal region with epidermal growth factor-like, lectin-like, and complement regulatory protein-like domains. Separating these N- and C-terminal regions is a nonhomologous glycosaminoglycan attachment region. In cartilage, the CSPG aggrecan (not included in this group) forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Unlike aggrecan which is widely distributed in connective tissue and extracellular matrices, neurocan is localized almost exclusively in nervous tissue. Aggregates having other CSPGs substituting for aggrecan may contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.
Statistics
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PSSM-Id: 143310
View PSSM: cd05902
Aligned: 4 rows
Threshold Bit Score: 191.997
Threshold Setting Gi: 189520501
Created: 29-Jan-2008
Updated: 18-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160332364   51 LAELVALPCLFtlqprp-----saardaPRIKWTkvr----tasGQRQdLPILVAKDNvvrvakswqGRVSLPSYPRRRA 121
gi 94733064    13 LSGSALLPCVFtlsps-------pshepPRIKWTklwgqrgpdgLQKQ-QSILVAKDNiikvkkafqGRVTLPGYPGNRY 84
gi 111306117   50 LAQSVALPCLFllhpshppqqpndtsesPRIKWSrlq----pgiGQKE-VPVLVARDNvvkvargyeGRVSLPGYPHNRY 124
gi 189520501  137 LSSSVLLPCVFtlpaaa-----sspphgPFIHWThg-------sGAQQ-RTVVSARDGvlrvhqafaGRLRLPGYSKNQL 203
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 160332364  122 NATLLLgpLRASDSGLYRCQVVRGIEDEQDLVPLEVTGVV 161
gi 94733064    85 NASLVLtgLRSSDSGMYRCEVVVGINDEQDTVPLQVTGVV 124
gi 111306117  125 NATLVLssARVSDSGVYRCEVIYGIDDEQDTVPLEVTGLV 164
gi 189520501  204 NASLELsrLRYNDSGTFRCHVALGENYEQDTVHLEVTGVV 243
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