Conserved Protein Domain Family
R3H_DEXH_helicase

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cd06007: R3H_DEXH_helicase 
R3H domain of a group of proteins which also contain a DEXH-box helicase domain, and may function as ATP-dependent DNA or RNA helicases. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to bind ssDNA or ssRNA in a sequence-specific manner.
Statistics
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PSSM-Id: 100077
View PSSM: cd06007
Aligned: 12 rows
Threshold Bit Score: 95.4579
Threshold Setting Gi: 167875095
Created: 27-Feb-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
RxxxH motif
Feature 1:RxxxH motif
Evidence:
  • Comment:The RxxxH motif gives R3H domain its name.
  • Citation:PMID 9787637

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                       #   #                         
gi 110741780   22 RIWATKVIEDFRASg-nEVYTFEHnLSNNERGVIHQMCRKMgIQSKSSGRGEQRRLSIFK 80
gi 53793557    48 LVRVSKVLEDFQASd-aQVYKFEPgISKQERAAIHEMCRKMgMISKSSGNGERRCLSVYK 106
gi 38505213    46 KIAVNIALERFRYGd-qREMEFPSsLTSTERAFIHRLSQSLgLVSKSKGKGANRYLTVKK 104
gi 111305697   38 KIAVNIALERFRYSd-qKEMEFPSsLTSTERAFIHRLAQSLgLVSKSKGKGPNRCLTLKK 96
gi 118104219   57 EIALNLALERFWYSd-dQEMSFPSsFTSTERAFIHRLCQSLgLISKSKGKGSSRYLTVRK 115
gi 156382101   22 KIAVKIALDKFRYDetqKELEFPSsFTAVERAYIHRLCLNLgLKSRSRGKGSNRFLSVSN 81
gi 15221547    18 GAWATKVLEDFRASg-nDSYVFEQqLTNSERGIIHQMCRTMgLRSKSNGSGEERRLSLFK 76
gi 168022099   32 RISIVDRLNQFKASn-eEELIFEAdLSNHDRAVVHDTCKKLgLKSKSRGYGDDRRVAVFK 90
gi 157344589   38 RIRISRALQEFRETh-nEVYTFEAnLTNHERAVVHEVCRKMgMTSKSSGRGSQRRVSVYK 96
gi 116061807   25 RIDIAKALEDFRADpnaSELEFPPnVDNHFRAVVHAECKKLgLKSKSHGKGDDRRVRVTK 84
gi 115653172   23 KISVDLAIQEFRHDeseTVLEFPAsFSNNERAYIHRLAISCgLKSKSKGKGSNRYLTLIK 82
gi 167875095   20 RIAIHYMIDKFVQDeklNEFDFPVsFTREHRAYIHDYVKNKsLKSRSHGKGNQRYLTIYK 79

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