1T77,1MI1


Conserved Protein Domain Family
Beach

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cd06071: Beach 
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BEACH (Beige and Chediak-Higashi) domains, implicated in membrane trafficking, are present in a family of proteins conserved throughout eukaryotes. This group contains human lysosomal trafficking regulator (LYST), LPS-responsive and beige-like anchor (LRBA) and neurobeachin. Disruption of LYST leads to Chediak-Higashi syndrome, characterized by severe immunodeficiency, albinism, poor blood coagulation and neurologic problems. Neurobeachin is a candidate gene linked to autism. LBRA seems to be upregulated in several cancer types. It has been shown that the BEACH domain itself is important for the function of these proteins.
Statistics
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PSSM-Id: 100117
View PSSM: cd06071
Aligned: 69 rows
Threshold Bit Score: 219.422
Threshold Setting Gi: 145344695
Created: 26-Apr-2007
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1T77_A        137 TQRWQHReiSNFEYLMFLNTIaGRSYNDLNQYPVFPWVITnyeseel---------------------------dltlpt 189
gi 47227770   166 VLDWVHGrvSNFCYLMELNRLaGRRQGDPNYHPVLPWVVDftv----------------------------------pfg 211
gi 149053395  345 VLDWVHGrvSNFYYLMQLNRLaGRRQGDPNYHPVLPWVVDftt----------------------------------pyg 390
gi 156384831  366 VDMWVRDeiTNFDYLMALNYHsGRRLGDPNYHPLFPWVVDfte----------------------------------ecg 411
gi 66828377   475 MNKWINGelSNFNYLMILNHLaHRHIGDPMNHPVLPWVIDfttspinidndndsrddvdnssssnnnnnnnnedqsgktv 554
gi 115761377  384 MQKWAMGqlTNFDYLMILNRLaNRQMGNPNHHPIMPWVMDftq----------------------------------pdg 429
gi 167521273  374 VEAWLLGgiSNFDYLMALNSHaGRRLNDPNHHPIFPWITDfsgs--------------------------------slgd 421
gi 24583787   345 TEMWCNGqlSNFDYLTILNNAcGRSLTNAAYHHIMPWVTDfsgr---------------------------------ggg 391
gi 163914652  236 TSNWANRkwENYQYLTYLNDItGRVRGEVHNHPIFPWVCDfse----------------------------------eng 281
gi 42567937   348 FDKWWKGelSNFEYLLVLNKLaGRRWGDHTFHPVMPWVIDfskkpe-----------------------------ndsds 398
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1T77_A        190 NFRDLSKPIGALnpkraaffaery------------------------------esweddqvpkfHYGTHYSTASFVLAW 239
gi 47227770   212 KFRDLRRSKFRLnkgdkqldftyemtkealaaavgng----vggsgvgdlsgsvgtggggqpehlHVPHHISDVLSDITY 287
gi 149053395  391 RFRDLRKSKFRLnkgdkqldftyemtr------------------------qafvaggagsgeplHVPHHISDVLSDITY 446
gi 156384831  412 GFRDLSKTKFRLnkgdhqldmmykq----------------------------swfesheggnseTVPHHVSDVLSEITY 463
gi 66828377   555 GWRDLTKTKYRLnkgdeqldfqffntgnsttlgddsmgggigsigstggitnssnngggggsgnsGKAHHISDILSELTY 634
gi 115761377  430 NYRDFSKSKYRLnkgdnqldftyesal-----------------------qmqamneedgsnlagQVPHHISDVLSEITY 486
gi 167521273  422 SWRDLTQSKYRLnkgdaql----------------------------------------dlawtgPDPHHVADILSELSY 461
gi 24583787   392 AWRDLTKSKYRLnkgdvhldlmyahas------------------------qhgsadgsyqaigdQAPHHVSDFLSEITY 447
gi 163914652  282 GFRQLNRTKYRLckgddql----------------------------------------remysrEPSHHVPELLSDIGY 321
gi 42567937   399 GWRDLRKSKWRLakgdeql---------------------------------------dftystfEFPHHVSDECLSELA 439
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1T77_A        240 LLRIEPfttyflnLQGGKFDhaDRTFSSISRAWRNSqrd-------------------------tsDIKELIPEFYYLPE 294
gi 47227770   288 FVYKARqtp--ksVLCSHVRs-QWEPNEYPASMERMqs---------------------------wTPDECIPEFYTDPS 337
gi 149053395  447 YVYKARrtp--rsVLCGHVRa-QWEPHEYPATMERMqt---------------------------wTPDECIPEFYTDPS 496
gi 156384831  464 HAYLARrtp--vsVLCEHLRs-NWVPNEYPASMKRLfe---------------------------wTPDECIPQFFTDPS 513
gi 66828377   635 YSYLARrts--vpLLRRFVRt-NYEPNEYPATMERLyr---------------------------wTPDECIPEFFTDST 684
gi 115761377  487 YIYKARctp--ksLLQTHVRs-VWVPNEYPASMQRLqg---------------------------wTPDECIPEFFSDAS 536
gi 167521273  462 FVLKARvtp--kdILCEHVRs-RWVPEEYPSSMHRHtqtlpappdtphlslprahlcftqermymvSPDECIPEFYTDPS 538
gi 24583787   448 FVYMARrtp--qsILCAHVRp-IWVPAEYPVSIQRLqe---------------------------wTPDECIPEFYSDPM 497
gi 163914652  322 MVYRARvep--kdNLCRHVRr-KWVPEEYPSTMSRMyq---------------------------wTPDECIPEFYDDPS 371
gi 42567937   440 VCSYKArrl-plsVLRKAVRs-VYEPNEYPSDMQRLyd---------------------------wTPDECIPEFYCDPR 490
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1T77_A        295 MFVNFnnynlgvmddgtvvsDVELPPWAKts--eeFVHINRLALESefvscqLHQWIDLIFGYKQqgpeavraLNVFYYl 372
gi 47227770   338 IFRSIhpd----------mpDLDVPSWCKsy--edFIEVHRRLLESrevsqhLHYWIDLTFGYKLsgkeaikaKNVCLHl 405
gi 149053395  497 IFCSIhpd----------mpDLDVPAWCSsn--qeFVTAHRALLESwevsqdLHHWIDLTFGYKLqgkeavkeKNVCLHl 564
gi 156384831  514 IFSSIhdd----------lpDLALPPWTPtp--tdFISWHRSALESdevsreLHNWIDLTFGYKLsgkaaikaKNVCLDl 581
gi 66828377   685 IFKSIhsd----------mpDLQLPDWVPnqstqeFIKIHMNALESdhvskqLHSWIDLTFGYLLsgeeaikaKNLALMd 754
gi 115761377  537 IFKSThdd----------lpDLEVPSWCKgp--edFVQRHRAVLESpyvserLHRWIDLTFGCKLsgsaavkaKNVVLCv 604
gi 167521273  539 MFRSIhad----------lpDLHLPAWADsp--edFIAQHREALESdyvtehLHTWIDLTFGYLLtgeaavkaKNVPYDl 606
gi 24583787   498 IFKSIhed----------lpDLELPAWATcp--edFICKHREALESqyvserLHHWIDLNFGYKLsgkaavksKNVCLTl 565
gi 163914652  372 IFNSChpd----------maDLRFPEFVSsp--qeFIEWHRKMLEHeevsmnLHRWIDLVFGFNLaidnsknaLNLHLCf 439
gi 42567937   491 IFCSLhps----------msDLAVPPWASsp--deFIRLHRDALESphvsslIHHWIDITFGYKMsghaaitaKNVMLSs 558
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
1T77_A        373 tyegavnlnsitdpvlreaveaqirsFGQTPSQLLIEPHPPR 414
gi 47227770   406 vdn-------------------htnlTTYGVVQLFDQPHPPR 428
gi 149053395  565 vda-------------------hthlTSYGVVQLFDQPHPQR 587
gi 156384831  582 vsk-------------------sqsvSNFGVVQLFTQPHPPQ 604
gi 66828377   755 tt----------------------ipRNNGIVQLFNHPHPKK 774
gi 115761377  605 vdq-------------------htlpANNGVVQLFNVPHPKR 627
gi 167521273  607 vgk-------------------rnvlKNSGVVQIFQAPHPAK 629
gi 24583787   566 vdq-------------------hrnlSQRGIVQLFASAHPPR 588
gi 163914652  440 vekn------------------rrglRTTGMVQLFNRPHPIR 463
gi 42567937   559 sep--------------------tvpRSVGRRQLFFRPHPVR 580
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