Conserved Protein Domain Family
MUM1_like

?
cd06080: MUM1_like 
Mutated melanoma-associated antigen 1 (MUM-1) is a melanoma-associated antigen (MAA). MUM-1 belongs to the mutated or aberrantly expressed type of MAAs, along with antigens such as CDK4, beta-catenin, gp100-in4, p15, and N-acetylglucosaminyltransferase V. It is highly expressed in several types of human cancers. The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins seem to be nuclear, often DNA-binding, proteins that function as transcription factors regulating a variety of developmental processes.
Statistics
?
PSSM-Id: 99903
View PSSM: cd06080
Aligned: 7 rows
Threshold Bit Score: 90.1876
Threshold Setting Gi: 145543276
Created: 8-Feb-2008
Updated: 17-Jan-2013
Structure
?
Aligned Rows:
 
putative
Feature 1:putative chromatin binding site
Evidence:
  • Comment:Based on sequence similarity to other PWWP proteins.

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                   #  #  #                        #        # #                           
gi 74762184   390 FETGMIVWFKYQKYPFWPAVIKSIrrk-------erKASVLFVEan-mnSEKKGIRVNFRRLKKFDckek-qmlvDKARE 460
gi 118103238  155 IDKGILVWCKWQRYPYWPAVVKNVkrk-------hrKANVLFIEgd-tsDKKKSFSVSLRNLKHFDceek-qdliDQAKK 225
gi 148668830  380 IERGTLVWFKFQDLPFWPAVVKSVsen-------dkMARVLLIEgn-mqFERRGIRVPLRKLKHLDcgek-vslvRRASR 450
gi 145476005    3 FNKNDVFWGKIQGYPYWPCTIAYDqpd-------kqKCRVFFFGdn--qQGELKYQDLKPFEEHFEhycsqakknNNLKI 73
gi 145543276   37 FEINEVVWAKVLGYPWWPAQISSIsngkt---gtnqSYRVNFLAdg--tHADCRLEKVKKWNDRPTqt-----etKKLKE 106
gi 145507810    9 YTKDEIVWAKIRGYPWWPGIIAEVikekq--sseptKYLVNFIGdnsqsSTLPFQSLAKYQEKYEEivqk--iktKQHKD 84
gi 118383355   10 YSKNDLVYAKIRGYPWWPGIIGEIkmkpgengekkyELLVNFIGdh-shSMVNEDKLQKFYVKEIDf-------kNKKRK 81

                  ....*....
Feature 1                  
gi 74762184   461 DYSESIDWC 469
gi 118103238  226 DYCQEIEWC 234
gi 148668830  451 LYAQGINWC 459
gi 145476005   74 SIEQAINKE 82
gi 145543276  107 AIELANQIQ 115
gi 145507810   85 SVTAADQIL 93
gi 118383355   82 KLMQSIQIA 90

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap