Conserved Protein Domain Family
RP_Saci_like

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cd06094: RP_Saci_like 
RP_Saci_like, retropepsin family.
Retropepsin on retrotransposons with long terminal repeats (LTR) including Saci-1, -2 and -3 of Schistosoma mansoni. Retropepsins are related to fungal and mammalian pepsins. While fungal and mammalian pepsins are bilobal proteins with structurally related N- and C-termini, retropepsins are half as long as their fungal and mammalian counterparts. The monomers are structurally related to one lobe of the pepsin molecule and retropepsins function as homodimers. The active site aspartate occurs within a motif (Asp-Thr/Ser-Gly), as it does in pepsin. Retroviral aspartyl protease is synthesized as part of the POL polyprotein that contains an aspartyl protease, a reverse transcriptase, RNase H, and an integrase. The POL polyprotein undergoes specific enzymatic cleavage to yield the mature proteins. In aspartate peptidases, Asp residues are ligands of an activated water molecule in all examples where catalytic residues have been identified. This group of aspartate peptidases is classified by MEROPS as the peptidase family A2 (retropepsin family, clan AA), subfamily A2A.
Statistics
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PSSM-Id: 133158
View PSSM: cd06094
Aligned: 16 rows
Threshold Bit Score: 134.671
Threshold Setting Gi: 47211608
Created: 15-Apr-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
Feature 1:inhibitor binding site
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                       # # #                    ###                                    # 
gi 44829173    99 FYVHDyrTNARYLVDTGAQVSVVPignsks---qatmlRLRAANGsVIPTYGtrqLTVNLSNrrqYLWTFIIADVptAIL 175
gi 115744330  143 FYVVDinSRVKFLVDTGAAVSVFPptkqqr--tcrstiTLKAANGsIIATYGrrsLTLNLGLrrkCQWVFVIADVsvPIL 220
gi 156539629  377 LHVSDrtSKLRFLVDTGSAISLLPrayfkrg-lrhaplTLSAANAsSISTYGshaLVLDLGLsrpFAWKFVIADVsnPIL 455
gi 156538899  245 LHITDqsTKLRFLVDTGSAVSLLPlahfket-rrrsplTLSAANAsAIATYGthsLTLDLALakpLNWKFIVADVsdPIL 323
gi 156541502  383 LHIQDriSGQFFLIDTGADISLLPavnsir--skpdslKLFAANGtKINTYGesyRTLDLGLrrpFAWNFCIAEVpsAII 460
gi 156539007  332 LHVLDrtTNTSFLVDSGSVLSLLPrsavrdrklavqplRLVAANGtPVHTFGrrlVTLNLGLrraIPWPFVVADVpvAIL 411
gi 156540320  455 LHVRDriSKEVFLIDTGADISVIPkpsnwq--gkptefKLYAVNGtTINVYGvarRELDVGLpykLAWNFTITDVphPII 532
gi 156542163  345 LFIRDpsTSILFLVDTGSVATLVPksliktp-lnkqplTLHAANKsEIATYGihrLELSLGLrrnFACEAIVADVphAIL 423
gi 156545090  194 LTLKDlkSGRRFLIDSGAEISVLPasykvn--skpssrKLYAANDtTIDTFGetfLLLDLGLnrpISWNFVIASVphAII 271
gi 51235680    23 LYVTDvtTKVRYLVDTDAEVSVLPanpddk--lresvfSLQAANGkPIATYGkryVYLNVGLrkpIHWIFVVADIamPII 100
                          90
                  ....*....|
Feature 1                   
gi 44829173   176 GIDFLQHYEL 185
gi 115744330  221 GADFLHHFRL 230
gi 156539629  456 GADFLAHFGL 465
gi 156538899  324 GADFLAHFGL 333
gi 156541502  461 GADLLSHHGL 470
gi 156539007  412 GADFLHHSGY 421
gi 156540320  533 GADLLKHYHL 542
gi 156542163  424 GADFLIQHSL 433
gi 156545090  272 GADILYHYGL 281
gi 51235680   101 GIDLLQYHNL 110

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