Conserved Protein Domain Family
YjgF_YER057c_UK114_like_2

?
cd06150: YjgF_YER057c_UK114_like_2 
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.
Statistics
?
PSSM-Id: 100007
View PSSM: cd06150
Aligned: 70 rows
Threshold Bit Score: 107.238
Threshold Setting Gi: 126730626
Created: 3-Apr-2008
Updated: 29-Oct-2018
Structure
?
Aligned Rows:
 
homotrimerputative active
Feature 1:homotrimer interaction site [polypeptide binding site]
Evidence:
  • Comment:based on similarity to other members of the superfamily

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1          ##  # #       # # ##                                  # ## # #          #  #  
gi 70734293   20 ARFSQAVIHn-----rTVYLAGQVSqlt-egdIRAQTQDVLQQIDALLARAGTDKGHLLSAQIWLKDmaDYPAMNLLWDA 93
gi 114766982  13 GRNSGTAFNg------MGWAVATTQvet--ddVHDQTASTLARIDEILAEMGTDKTRILNATIYVTDiaTKDEMDRAWCD 84
gi 153832309  10 QGRNKSSAYk-----dLVWTVATSSdtt--lgIVEQTELTLRTIADNLRELGSDKTRIVSAQVYIANmkDKPLMDEVWCE 82
gi 27375365   15 PSKSAVTTYhmpggggLLWAVAVSPdrt--qdIRIQTLGALGVIDTYLKDAGLDRTRIVKAEIVVTDhdNKPAFDEAWAS 92
gi 89054145   11 IGKCSAAVHg-----gLAYIVANAPepg--egILDQTSGCLAELDRLLRSVGSDRTRVLQVTVYLSDiaDKPRMDSIWMP 83
gi 27382300   10 PIMHRAVEAn-----gFVFFGGTIAddt-svsMGDQTRNILGKIAGYLKEAGTDKSRVVSASIFVTDlsKKKEMDAAWTE 83
gi 160935863  10 KHFARVTEYn-----gVLYFTGHIAagk-qptMTEQMVALTHRLDELLEQFGSDKNHILYAKINIHDwsMFDEFNAVWDA 83
gi 163700825  10 GLLHEVVAHg-----gVLYFAGIVAent-dldIAGQARDVLTQLDALLLAHGSDRQHVLQATAYLVDlgEKEGLNRAWKE 83
gi 27376573   10 GLLHEVVEHg-----gVLYIGGIVAedt-sldMSGQANDVLGQLSRLLKTLGSDLANVLQVTIFVTNlgEKAAFNAAWKA 83
gi 145345091 860 LDCSPVVTWg-----rQVWLSGITCggvveptFTGQMRRVFDNLVRLLVMAGTDVAHLLQVKIHLKDirEMEAVCDIWDR 934
                         90       100       110
                 ....*....|....*....|....*....|....*.
Feature 1         #         #########         # # #  
gi 70734293   94 WLeg-----vqAPVRACVQAPMAkphYRIEVLVIAA 124
gi 114766982  85 WIgdd---pqhWPQRACVETGLAa-gHRVEIVVVAA 116
gi 153832309  83 WMgdn---sdhWPQRACLGVDLEg-dVLIEVTVTAV 114
gi 27375365   93 WMpa-----gyGPVRSFVQSVMPd-gDLIEIIITAA 122
gi 89054145   84 WIgae----enWPQRACVGADLDp-gYLIEIVATAV 114
gi 27382300   84 FFgd------nLPTRATVGVADLggsALIEVVVTAL 113
gi 160935863  84 WFdp-----gcMPARTTAQSVLTd-gYLVEITLTAA 113
gi 163700825  84 FFga-----ahLPARATIGVQDLgrdVRLELVVTAA 114
gi 27376573   84 HFae-----ahLPARAVVGVADLgsgVKLEMTAIAA 114
gi 145345091 935 FFsdagitrehRPCRHITQAVLSnakLQVEMFAEAV 970

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap