Conserved Protein Domain Family
YjgF_YER057c_UK114_like_3

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cd06151: YjgF_YER057c_UK114_like_3 
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.
Statistics
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PSSM-Id: 100008
View PSSM: cd06151
Aligned: 17 rows
Threshold Bit Score: 153.63
Threshold Setting Gi: 111019009
Created: 17-Apr-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
homotrimerputative active
Feature 1:homotrimer interaction site [polypeptide binding site]
Evidence:
  • Comment:based on similarity to other members of the superfamily

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        ##  # #     # # ##                                                           # #
gi 118049672  47 IAAAVEIptdarTVYLSGKVPpvvdksrta--------------tdpaayggdTEGQTVAILKGLEEQLKSMNltmsDVV 112
gi 159471730 197 ILSGVTVpatyaVYWSSGTVPavknasapa---------------gsrerfgnTTEQAISILERMSTLLAEAGltlaDAT 261
gi 111019009  54 IAQGVAIgggtaVYKSSGIGPgasnktapegtpesyidtdvfaggalpagvtiTEAQGINALKRIRDNLEAQGltleDVV 133
gi 159471730 352 ILSGVSVptghaYYHSSGTVPaaknasapr---------------gsrerygnTTEQAISVLTRIQALLREQGlgmqDAV 416
gi 58039628   48 ISAAVQVpagaeTVYVSGLGPapdra-----------------------sgttTAEQTRSALDQISGALGHFGmtlqDVV 104
gi 116694385  51 FAEVIEIpanaqLLVLSGVGPtvanasapp---------------dtaasygdTATQTRSVLGQIERILQDRGyrmgDIV 115
gi 28870184   15 ISQTVTVpasasLIFISGTLPdladphapa---------------gtpaaygnTQVQTVSVFNKLRRILQQQDldlgDIV 79
gi 169184996  52 ISSAVAMpagtaTFETSGTVPsvvnkegk----------------tiyerygdTEKQGLSVLKNIETLLKEQGlsmkDVT 115
gi 124002440  49 ILRGVAIpkgkkTFLTSGLVAplldstaak--------------tnahkrrgdTYTQSIHTLQRIEKILQEAGlemkDVV 114
gi 162148237  38 IATAIEVppgasTIYLSGTGAqpvnksakp---------------mtlaaygdTETQVRGALTQIQGQLAKLKltmgDVV 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        # # #                #  #   #                             #########          # #
gi 118049672 113 KMQVFLvadpakgnkmDFAGFMRGYTQFFgtaa----------------------qpnLPARSAFQIaalanpaWYVEIE 170
gi 159471730 262 YLRVFLvadphlnntvDYQGWFNAYALYFskp-----------------------gsvKTARSTMAVtslvnadWLIEIE 318
gi 111019009 134 TMRVFLdnapg-tdraDYAGWNRAYRQFFantnldtgdtelvplgtaepaapmernsaRPSRFALEVaslpaagWLVEVE 212
gi 159471730 417 YVRCYLvadpflngtvDFAGWNVAYAQFFnip-----------------------gstRVARSTLAVaglvdaeWLVEIE 473
gi 58039628  105 QMHVYLvadpr-lghmDFDGMMQTYRARFrs--------------------------gFPARTVIEVphltnqhWLVEID 157
gi 116694385 116 SMQALIvadpa-tgepDFTGFSSAYKQYFgtdk----------------------qpnVPVRTRAEVlrlvppgWLVEVT 172
gi 28870184   80 QLRVFLvgaeetggklDFAGLQAGYTQFFgtpe----------------------qplKPARTALQVvalplpgALIEVE 137
gi 169184996 116 YLRVYIapdaakdgkfDFDGWNKAYAKYFntke----------------------npvKTARSTVGVaslvnsdWLIEIE 173
gi 124002440 115 YLRVYIapdaqnsqepDFDAWFKAYNKFFnnaq----------------------nptKVARTTLGVyrlarpdILVEIE 172
gi 162148237 103 QMHIYMvadpk-lgkiDFPGMMKAYTEFFgtka----------------------qpnLPTRSAFEVahlanpgWLVEIE 159

                 ...
Feature 1         # 
gi 118049672 171 VVA 173
gi 159471730 319 LWA 321
gi 111019009 213 VDA 215
gi 159471730 474 LVA 476
gi 58039628  158 VVA 160
gi 116694385 173 VMA 175
gi 28870184  138 AVA 140
gi 169184996 174 AVA 176
gi 124002440 173 AVA 175
gi 162148237 160 VTA 162

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