Conserved Protein Domain Family
YjgF_YER057c_UK114_like_4

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cd06152: YjgF_YER057c_UK114_like_4 
YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.
Statistics
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PSSM-Id: 100009
View PSSM: cd06152
Aligned: 17 rows
Threshold Bit Score: 166.328
Threshold Setting Gi: 46110561
Created: 3-Apr-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
homotrimerputative active
Feature 1:homotrimer interaction site [polypeptide binding site]
Evidence:
  • Comment:based on similarity to other members of the superfamily

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1          ##  # #   # # ##                                                  # ## # #    
gi 159122241  20 FKYSQAVRVGD-RIECAGQGGWNpstgtiPRDINAQIDQAFANVDLNLRNAgg-----------aGWSQVYRVNSYHvpi 87
gi 145228543  20 YGFAEACIAGD-RMEIAGQTGMSptstdvPPTLEEEVAQAFNNINEVILYTlekakpdlrasvksGWDRVVKIRTYHvql 98
gi 51492573   20 LHYSQAMRIGD-RVEISGQGGWNddl-viPESIEEEIEQAFKNVERTLATAg------------aRWPHVVHVNSYHvgg 85
gi 156031249  21 FWYSQAVQVGD-VIECSGQGGWDriteeiPKDIEKEIEQAFDNVEAALTTAgs-----------kGWEDVFSLTSHHmpi 88
gi 145603546  20 ANYSQSVRLGN-EIKTSGQGGWDtqtgkiSEKYEEELDQAFDNLDVALKDAgg-----------kGLEQVYKVNMYLtie 87
gi 40740196   21 FHYSQAVKVGN-IVKTSGQGGWTqdg-siPSDIERQVALAFENVENALRAVda----------rlSWQNVYAVRSYHidv 88
gi 46110561   21 NHYEQAVDLCNgFYKISGQGGFTdkg-emPSDVKDEVEQAVQNVEDVLKAAgl-----------rGWEDVYYVRHYHtdi 88
gi 46110555   20 YSYSQAVRVGN-TIKCSGQGGWDdqgnidKEDLKGQIDLAFKNVEKNLKDAga-----------rGWADVHSVRSYHisl 87
gi 152981954  20 LHYSQAVKIGN-RVETSGQGGWDdef-nfPESIEDEIAKAFDNLTRTLAAAg------------aSWEHVIHVNSYHvgg 85
gi 118471355  24 LHYSQALRIGD-RVEISGQGGWDddi-nfPADLEDEIVRAFDNVERTLATAg------------aGWPDVVSVNSYHvpt 89
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
Feature 1                     #  #   #   #########          # # #  
gi 159122241  88 -----ndeALEAMVRNFRKWVPghEPIWTCVGVTRLgeddMRVEIEVVAH 132
gi 145228543  99 pq--trekIIGLMVENVKKWCPdhQPTWTMLGIEALpfegQNLEIEVDVF 146
gi 51492573   86 f----ppvINETMAKLYRHYMPdrAPIWTQLGIEALglptMRIEIRVTAI 131
gi 156031249  89 -----ndeTMGIMVRLLKKYCPnhQPIWTALGVPALartdMRVEIEVRAY 133
gi 145603546  88 m----teeVFGQTAAVLKKRFPnhRPLLTVVGVTTLafpeMHVEIEVSAY 133
gi 40740196   89 ------skTFDVVTANFKRVLPnhRPVWTCVEIGKLgiegMEIEIEVEAH 132
gi 46110561   89 ------dvTLPLVTEAVKRKVPnnRPGGVAAGVTRLalpnMRIEIEVDAK 132
gi 46110555   88 ------sgSFDLMVEEFRKWMPdhQPTWTCVGVTELgipgMIVEIEVEAN 131
gi 152981954  86 f----ppeVNATMVKLFRHYMPkhSPIWTELGVAALglpqMRIEIRVTAI 131
gi 118471355  90 apdtigddHTRVMVEQFRKRMGdrAPIWTQIGVPALgvpgMRVEIRVTAV 139

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