Conserved Protein Domain Family
YjgF_YER057c_UK114_like_5

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cd06153: YjgF_YER057c_UK114_like_5 
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.
Statistics
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PSSM-Id: 100010
View PSSM: cd06153
Aligned: 25 rows
Threshold Bit Score: 126.988
Threshold Setting Gi: 153892132
Created: 17-Apr-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
homotrimerputative active
Feature 1:homotrimer interaction site [polypeptide binding site]
Evidence:
  • Comment:based on similarity to other members of the superfamily

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        ##  # #               # # ##                                                   #
gi 26990489  261 FSRAVAIlgd---------aqaMVFVSGTASIIGAksv-hvGNIEQQTRQTLENINNLLSARllsdydcy--patsgleS 328
gi 116622858  39 FVRGMRIdln---------gltILLISGTASIDENgvsvhiGDFRAQLRRTYQNITGLLEAEgat------------whD 97
gi 29349837  266 FERGKSLsdh---------qqeMIYISGTAAIRGEesi-vtGDVLVQTEITLENIQHLIGLEegrekl------pehsgK 329
gi 29347885  264 FERGTYVdyg---------drrQVFISGTASINNKgevvypGDIRRQTERMWENVEALLKEAect------------fdD 322
gi 153892132  40 FSRTVEIaesdgagetgegggrHQLVSGTASIDPAgrtahvGDLDAQIDLSLRVVAAILESRgmg------------wtD 107
gi 177841251 278 FSRGMTLaie---------grkIVHISGTASINSAgasthvGDAECQSLETLMSIAAILEEQggs------------lkN 336
gi 118579242 272 FERGTSVafg---------drkHIFISGTASINHKgeimhrNDVVRQLNRTFVNIMALLADAgag------------meN 330
gi 150007279 260 FERAKSMtfq---------drkLIYISGTAAIRGEesl-tgVGLERQLRITMENIAELIADA-----------------K 312
gi 86136402  217 FARGTLRraptlv----ggagtRFFLSGTASIRGAdti-wpGDIGRQITTTMENIRFLISDEnpqmaqq---gqamdlaS 288
gi 171913595 198 FARAVLVteg---------gttTGYLSGTASIEGHrtv-geGDWHTQFRTTMHNIEIMFDRMdmmealrgpeaaakagiV 267
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
Feature 1         ## # #           #  #   #         #########       # # # 
gi 26990489  329 IVSYTVYIKrr-eDITVVRAVCAALLpe-----rAVATFVQADVCRteLLVEIEAVA 379
gi 116622858  98 IVRTTCYLRdierDYEAFNEERTAFFreqqldpmPASTGIQAILCRpeLLIEIEAIA 154
gi 29349837  330 LELLRVYLKhe-eDAKIVKEDMDKLCp------dVPIVYLYADVCReeLLVEIEGIA 379
gi 29347885  323 LGHMIVYLRdi-aDYAVVKSMYDKCFp------dTPKVFVHAPVCRpgWLIEMECMG 372
gi 153892132 108 VSRAILYFPdi-sWMPRFEAHRAALGlp-----pIPGIYAHCDICRddLLFEIELDA 158
gi 177841251 337 ITSATLFCKdr-aAWEAWERVTRLLQip-----aLPKVCVIADVCRhdLLVEMEAVA 387
gi 118579242 331 VAQMIVYLRdp-sDSETVNAYLDENYr------nIPNIVTLAPVCRpgWLVEVECIA 380
gi 150007279 313 LVKLRVYLKnk-sDYKEAERLMNTYGl------nIPISYMWADVCRdeLLIEIEGIA 362
gi 86136402  289 FDHFKVYFRhv-eDYECIRKILTQDWqi----aaEKLHFMNVDICRsdLLVELEGCI 340
gi 171913595 268 RRDFKCYLRha-eALPLIKDWLTEELgl----asHQATFLQADICRqeLDLEIEAVV 319

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