Conserved Protein Domain Family
YjgF_YER057c_UK114_like_6

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cd06154: YjgF_YER057c_UK114_like_6 
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.
Statistics
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PSSM-Id: 100011
View PSSM: cd06154
Aligned: 49 rows
Threshold Bit Score: 140.767
Threshold Setting Gi: 55232197
Created: 17-Apr-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
homotrimerputative active
Feature 1:homotrimer interaction site [polypeptide binding site]
Evidence:
  • Comment:based on similarity to other members of the superfamily

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                    ##  # #  # # ##                                      # ## # #       
gi 6457694    33 IAGTSPWEDTvGYSRAVRVGnIVQVAGTTAtvdgevvgvgdAYWQTKVALGLIRQALEQAGARLEDVVRTRMYVpdisRW 112
gi 121609889  14 IQSGSRWEELaGYSRAVVDGdDILVSGTIGqdfasgqfppsASAQCELALDTIEAALAQAQATLADVLRVRVYLadraDV 93
gi 16263641    5 IFAGVPSEEMaGYAKAVIVGtTVYVSGTTGrdpdtgnfpdnAAQQARNALASIDKALRQAGGSLANAVVSRVYVvdqaCA 84
gi 118592878   5 ISSGSPFEKIgGYSRAIVDDdWVFISGTSGyvege-teaddAVGQTKKALEIISSTLAEAGGGLRDIVSLRVYVarreDI 83
gi 84686588    6 ITSGSPFEAQiGYSRAVAVDgWVFVSGTTGydyatmempadVAQQAANALATIGKALAEAGGSLDDVVQVKYILpdgnDF 85
gi 163796869   6 IYSGAPFEEMaGYARAVVDPpYVFVSGTTGfdpetlqfpedVESQCENCFATIERALAKAGASLNDLVRIRVFVasraEF 85
gi 23013320    6 ISSGSSFEEVaGYSRAVAQDpWVFVSGTSGfkdgq--iadgVVAQAEQCIATIAGALEQAGSSLKDVVRVKAYIteaaFF 83
gi 56677643   57 ISSGGPFEAKiGYCRAVVAGgFVHVAGTVGqg-------edVVAQCRSALEVIGAALKEAGAGFADVVRVTYYLpdaaEF 129
gi 37679749    7 VKTGSKLEEIaSYSRVVAVDnWIFVSNTAGrnpetgempkdVFEQTEQVFTNIEVALASVDASLKDVITSKVFIqnpdNV 86
gi 88798402    8 YSLDSTFEKLlNYSRVVVDDeWVFVSGCSGfdysdmsiadtMTEQVEQTFKNIQWCLSQAGAVFEDVVRIRVIVadrdHY 87
                         90       100       110
                 ....*....|....*....|....*....|....*....
Feature 1           #  #   #   #########          # # # 
gi 6457694   113 EQVGRAHGEVFGaiRPAATMVQVaalidprHLVEIEAEA 151
gi 121609889  94 LAVSQVLRRRLGhnRPANTTLCCala-vegAKVELEVSA 131
gi 16263641   85 ADVTAVLGEVFRdiRPTSTMLICeip-apgAKVEIEITA 122
gi 118592878  84 LDIAKHLGTVFQdpRPTNTTVTCgfv-ndeIKVEIEVTA 121
gi 84686588   86 EACWPVLSKAFAtaRPAATMIEArlm-npeMKIEIEAVA 123
gi 163796869  86 ERIKPIIKRHCDaaRPANTTVLAelv-epyMRVEIEVTA 123
gi 23013320   84 EQIAPVLGKAFKgiRPANTTIVCglv-dprMKVEIEVTA 121
gi 56677643  130 EPCWPILAETFGanPPAATMIECgli-dpkYRIEIEVTA 167
gi 37679749   87 PAVMEFVGTKFRgvNPTTTVTCPplg-stiYEVEIEVTA 124
gi 88798402   88 NEAATVIGRYCAqaKPANTTWFAelp-dprIKIEIEVTA 125

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