Conserved Protein Domain Family
eu_AANH_C_1

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cd06155: eu_AANH_C_1 
A group of hypothetical eukaryotic proteins, characterized by the presence of an adenine nucleotide alpha hydrolase (AANH)-like domain located N-terminal to two distinctly different YjgF-YER057c-UK114-like domains. This CD contains the first of these domains. The YjgF-YER057c-UK114 protein family is a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.
Statistics
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PSSM-Id: 100012
View PSSM: cd06155
Aligned: 30 rows
Threshold Bit Score: 91.1645
Threshold Setting Gi: 66816621
Created: 16-Apr-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
homotrimerputative active
Feature 1:homotrimer interaction site [polypeptide binding site]
Evidence:
  • Comment:based on similarity to other members of the superfamily

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         ##  # ## # ##                                        # ## # #          #  #   #
gi 118091817 306 SSGKSVTGYQWFSCITAqfhps--kdknAQEAAREAFSSLQATITSEglk--lkDIILVHLYMKSmkDFNVINSVYVTEF 381
gi 158301423 418 RAIVNSKGWMWVAGVQGcg-------qdSRQAMASALATLEEMIQSHsft--lrQICYITLYVRNmtEYSFINEIYSTVF 488
gi 115894385 325 SCQCSNQGFAWVYGVRAtckae-ystssILLSTQVAMETLNEQLQSNgys--lkDAVLIHLYVRNmsDFASINSVYCQYF 401
gi 148233008 304 SSDRSQSGFQWISEIKTng-------gnVLEASHMGLSSLKDQAQELglq--msDAVLVHLYVKSmeDFAEINTVYGTHF 374
gi 85726382  462 RAAINAKGWMWLAGIQGsgt------egIEQGMQQALDTLRDLCQAKgyd--lqDLCYVTLYVRSigEYPLLNRVYHRAF 533
gi 48101080  327 IVNKNQTGWFWFGGIAGkh-------pdAKSAMREALEKLSSLVKKEnlq--isDIVAVTLYIKDmsNYISINEVYISCL 397
gi 157123063 284 LIEKVTNAKQRRSEQCHga-------etSSQAMEIALKTLEDLITSNsft--lrQICYITLYVRDmnEYSYLNAIYSEKF 354
gi 66816621  335 SSTTTKINDNDIDNDKDdy--------nIGELLDKALLNISNILKENsls--idQLLYVNLYISDmkDFSIVNQYYYKYF 404
gi 116059781 315 LVRYVTIERGSVANVSCsarpmdgrdatHETCAEAIFQCMGELVRNMpvsttfkKIAMTHVYLDDmsQFAKVNAVYSKYM 394
gi 71021825  323 PSIRRKGRYFGMSNVTGvtsss--thtsVEDQVKNAFNTIKELLTSSckglgmeHVTHINLYLGTqtLFGRINSMYRTMF 400
                         90       100       110
                 ....*....|....*....|....*....|
Feature 1            #########          # # #  
gi 118091817 382 d-lCPPARVCVETllp--dgVLFCIDCLAH 408
gi 158301423 489 afpNPPTRVCVECplp--adCAVVLEAVAF 516
gi 115894385 402 k-lNPPARVCVQAdlp--egTALQLDCLAH 428
gi 148233008 375 l-sAPPARVCVQCclp--dnASLKMDALFC 401
gi 85726382  534 dfhNPPTRVCVECplp--dgCHVVMEAIAY 561
gi 48101080  398 skiNPPVRVCVECpl----nIHVVLDAIAY 423
gi 157123063 355 gftNPPTRVCVECplp--enCHVVLEAVAF 382
gi 66816621  405 k-nNPASRACIEIplskndkTKFLIDCIGA 433
gi 116059781 395 psiEPSARACVATcls--sgSKVQIDCVFV 422
gi 71021825  401 g-vSPPTRACVALasl-prgCDLMINAVAF 428

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