Conserved Protein Domain Family
eu_AANH_C_2

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cd06156: eu_AANH_C_2 
A group of hypothetical eukaryotic proteins, characterized by the presence of an adenine nucleotide alpha hydrolase (AANH)-like domain located N-terminal to two distinctly different YjgF-YER057c-UK114-like domains. This CD contains the second of these domains. The YjgF-YER057c-UK114 protein family is a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.
Statistics
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PSSM-Id: 100013
View PSSM: cd06156
Aligned: 26 rows
Threshold Bit Score: 87.3847
Threshold Setting Gi: 116059781
Created: 7-May-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
homotrimerputative active
Feature 1:homotrimer interaction site [polypeptide binding site]
Evidence:
  • Comment:based on similarity to other members of the superfamily

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        ##  # #                  # # ##                                                 
gi 159125167 529 YSQAMSIplrg-----------aerIVYIAGQIplepasmqmvcdsapteerswlsdYSLRAVLSLQHMWRIGVTMqv-- 595
gi 71021825  458 YSQGIVQa----------------eKIWISGQIgllpad------------lslpedEHLQTALSIQHVRRIYKAMmndm 509
gi 58260330  407 YSQAVLVa----------------sRLHLAGQIplipasltlp-----lapalpkspYPHQATLALQHVGRIVQALksrn 465
gi 115894385 471 YSQAVQIv----------------sLVFCAGSIalcpsnm-----------tiieggINAESRLSLRSVARVLAAMhpgm 523
gi 118091817 441 YSQSIKVg----------------dILYCAGQIglvpctm-----------klvsggVWTEAAVALSHVEKVLQAMsqkt 493
gi 49119549  435 YSQAVRVg----------------pGLFCAGQIalkpctm-----------qlvsggATVEAQVSLLHVERVLDAInpgt 487
gi 85726382  610 YSQSTRIg----------------dITYISGQIalvpgsm-----------tiieggIRPQCKLTLRHISRIAKAMnahg 662
gi 156407436 107 YSQAVKAg----------------aLMFVSGNIglwpasm-----------klvdggVSTQAALSLRHVDRIVSAFsahg 159
gi 76153554   29 YSQAIAVpisniqlddcstscvthyFTFYSGQIglipelealpt--ksghfpshfdaLQAESWLSLRHCHRLMKYMsptd 106
gi 116059781 448 YGQSISVd----------------gLAYVAGQIgmeptt------------ldlvpgIVPQLERAMRSAVAVADITgap- 498
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                # ## # #                             #  #                               
gi 159125167 596 -------dWWLGAVAFItgae---------------niaaKAQVAWHIWETMnrkrddesideeessfdvwdikygrrte 653
gi 71021825  510 ggrhvdkgWVEGGLCWVdd-------------------edMVEIARRAWISQcdgqdqedeesereea------------ 558
gi 58260330  466 atgggwegWVEGAVGWWaksgd-------------gesgeGVQVTRDAWRIWtrrn------------------------ 508
gi 115894385 524 -----glnHVVMATCYVte-------------------pgSEVSARRHWDQAlkeekhqlee------------------ 561
gi 118091817 494 -----tlrHVITAICYVtd-------------------skHIPVAHSIWKKKlrdctkvedp------------------ 531
gi 49119549  488 -----tlaHVLLVQCYVtn-------------------rsYIPIALAAWAGKnehe------------------------ 519
gi 85726382  663 -----qlrDVVHGICFVth-------------------paFIGEARRQWERRtt-------------------------- 692
gi 156407436 160 -----nlrNTLSGVCYLtc-------------------aqHIPVARKAWSLAtrakrald-------------------- 195
gi 76153554  107 -----lwmNLFLGICYAad-------------------esSLSYARNCFHQAvclqtlditd------------------ 144
gi 116059781 499 -----lgaRSLAVTLYTnakyedeyaaagasahpanvmfeSFSREVDSSDRVfs-------------------------- 547
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
Feature 1                                ########         # # # 
gi 159125167 654 eqtpkatvsasipnfevlrssgvtPPFLAVQVeelpraSDIEWQGLG 700
gi 71021825  559 --------kawlgqpstgesrlppMLFVVLPRhclprsAAIEWQITA 597
gi 58260330  509 --------------------ggerAPIAFVQAkelpkgALVEYQVNL 535
gi 115894385 562 --------------ldsneypsipCLMNCVVVpslpkgGCVEWHVVA 594
gi 118091817 532 --------------eaynevaaecGMLAVVVVtnlprdAAIEWHVTA 564
gi 49119549  520 ---------------------adlAPVTVAIVpmlprgASVEWHVIA 545
gi 85726382  693 -----------------------nAIMDYIVLpalpreALVEWQVWA 716
gi 156407436 196 ----------------ddssddvdGLMAYIVVpnlpkeALVEWQVAC 226
gi 76153554  145 ---------------tygdtchcnKCVVWFIVsnlpknASVEWQWIT 176
gi 116059781 548 ----------------------wrPLVTQLVVtdlpkgAIGEIEPIL 572

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