Conserved Protein Domain Family
S2P-M50_like_1

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cd06158: S2P-M50_like_1 
Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the S2P/M50 family of RIP proteases use proteolytic activity within the membrane to transfer information across membranes to integrate gene expression with physiologic stresses occurring in another cellular compartment. In eukaryotic cells they regulate such processes as sterol and lipid metabolism, and endoplasmic reticulum stress responses. In prokaryotes they regulate such processes as sporulation, cell division, stress response, and cell differentiation. This group includes bacterial, eukaryotic, and Archaeal S2P/M50s homologs with a minimal core protein and no PDZ domains.
Statistics
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PSSM-Id: 100079
View PSSM: cd06158
Aligned: 97 rows
Threshold Bit Score: 77.9721
Threshold Setting Gi: 121726673
Created: 6-May-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
active siteputative
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                      ##  #                                                             
gi 81341333   14 TLMKILALLIAIIGHEIMHGLSAFLFGDRSTKDArRLSLNPIRHLD--MMGSVLLPalllifqapflFGWAKPVPvdmry 91
gi 134102898  39 VLIVLGGWATSLCLHEFGHALTAYRGGDLSVRSKgYLSLDPRHYTD--PVLSIVLPllf-----vaiGGIPLPGGavwin 111
gi 159039083  52 FLFVVSGWLVSLCLHEYAHALVAFRAGDRSVAHQgYLTLNPLKYSH--PLLSIAFPvlv-----vllGGIGLPGGavwvd 124
gi 81550422   44 FLFVTAAWVVSLCLHEYAHARTALHSGDISVGAKgYLTLNPVKYTH--ALLSIVLPvlf-----vimGGIGLPGGavfie 116
gi 81534329   75 FAFVAAAWVLSVGIHEFGHAFTAYKAGDTTIVEKgYLTLDPLKYSD--LFTTIIIPlva-----lalGGIGFPGGavylr 147
gi 72160892   73 FLLLLGGWLICLTLHQYVRSLLAYRGGDRALRGSgYLKLNPFAFRE--LGAQVVLPvaf-----lllGTFGLNGPavhvd 145
gi 2496075    35 FIISLIAVGSGFIFHELMHRTVARKYGAWSEFRA-WYEGLILGFILklVFGATFIApg--------aVYIYKDYLtp--- 102
gi 163799033  39 LIIALIAVGTGFIFHELGHRTVAKHYGAWSEYRA-WYEGLAIAMILrvILGITFIApg--------aVYISKDYLty--- 106
gi 74509616   47 LPATLITVGLGFVLHEIAHKLMAIRYGFWAEYRL-WLEGLLLALVTa-YFGFVFAApg--------aVYIHGNYIer--- 113
gi 74542305   46 IIIPYIVALLAIIPHEIGHRQAARRYGCFSRFTL-SFSGFWTTLILn-IIGSFVGIlvf------fsGYTSISCGlln-- 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                 #      
gi 81341333   92 ivsqkgslaCVVVSLAGVAYNFTLAVLLAFIThwsfqqlginalsidelnlyqlalvtfLIQGILYNLVLGVFNSLPIPP 171
gi 134102898 112 hhalrtrrvESMVSLAGPLTNLVLGIALTAVVvsvpmp---------------eglgsgLSYLAYLQVIAFVLNILPIPG 176
gi 159039083 125 rhaipgrlrHTLVSLAGPATNVVFTLVLVVAVrlaatggg------------pvefwaaVALLAFLQLTASLLNLLPVPG 192
gi 81550422  117 rgrirgrwrHSLISAAGPLTNVLFAVVCTAPFwldaldgv------------prdfrlaLAFLALLQVTAAILNFLPVPG 184
gi 81534329  148 edlmrsrgwRSLASLAGPLGTLVVLVVIAVSLplaaas---------------pplfnaLSLLAMLQASALVLNLLPVPG 212
gi 72160892  146 rs-avtrpfRVLAALGGLATNVVLAAVLAVTVallvpagqv----------tnnwaigaVMFLCFLNVSAALLALLPVPG 214
gi 2496075   103 -------eeNGKIALAGPLTNVALAFVFFILMlifkpg---------------sllywiGIFGFHINLFLAGFNMLPIPP 160
gi 163799033 107 -------eeNGKISIVGPLINFGLAFIFLIPMvlsvsmn-------------niylwtlGSAGFLVNITLAWFNMLPIPP 166
gi 74509616  114 -------dvNGKISLAGPLTNIILAIMFLMVStvlps-----------------pinqvAFLGYAVNSFLALFNLIPLAV 169
gi 74542305  116 ------rdvEGKTALAGPLTNIIVGFVGLIGAslvpfs----------------lvglfFFELARFNFWVAFFNLLPFWV 173
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
Feature 1         #                                          
gi 81341333  172 LDGSKALGFlalhfksafllewfskmerYGLLVVFIFLFIPPLS 215
gi 134102898 177 LDGYGAIEPwlsgpare----fgekarpWAPLVLFALILATPLG 216
gi 159039083 193 LDGGNMIQPwltppyrr----aydlfapYGFLLLFALLWNPRIN 232
gi 81550422  185 LDGYGVIEPwlsynvrr----qveplapFGLLIVFALLWIPALN 224
gi 81534329  213 LDGYGVIRPflpegvqa----rmmkverVGFLILFALIFWAPGV 252
gi 72160892  215 TVGYDILTEavnrwrp------srnaaiFGTVLLFAAVWCPPIH 252
gi 2496075   161 FDGEKVLKWn-----------------pFIWAIVGLPLIGYMLY 187
gi 163799033 167 FDGSKVLSWn-----------------kGIWLGVFAVFTVFWLF 193
gi 74509616  170 LDGAKVFRWn-----------------pLIWLLAAAAAFGLTFN 196
gi 74542305  174 LDGLKIFRWn-----------------mIVWAVLIIIAFALTFL 200

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