Conserved Protein Domain Family
S2P-M50_like_2

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cd06160: S2P-M50_like_2 
Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the S2P/M50 family of RIP proteases use proteolytic activity within the membrane to transfer information across membranes to integrate gene expression with physiologic stresses occurring in another cellular compartment. In eukaryotic cells they regulate such processes as sterol and lipid metabolism, and endoplasmic reticulum stress responses. In prokaryotes they regulate such processes as sporulation, cell division, stress response, and cell differentiation. This group includes bacterial, eukaryotic, and Archaeal S2P/M50s homologs with additional putative N- and C-terminal transmembrane spanning regions, relative to the core protein, and no PDZ domains.
Statistics
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PSSM-Id: 100081
View PSSM: cd06160
Aligned: 48 rows
Threshold Bit Score: 89.5966
Threshold Setting Gi: 74533386
Created: 23-Jan-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
active siteputative
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                          ##  #                                         
gi 75543517  184 VGFAVLSALILWPFFglhlgGLALAAILTSVVALHELGHMAAFRLMGHrKARMIFIPlLGGIAIGGRpy-nsRFEVAFVA 262
gi 90022952  135 VALLAASVGVYSVIF-----TPQFAVALVAILMFHEYGHIRGMKKFGIpTKGIYLIPfFGGMAIGEKhk--sQWQDVYIS 207
gi 87308431  277 ITMLVISFLLFAAAIgw-qqDFTALLLLAPILLFHEAGHFLAMKLFGYrDTKMFFIPfFGAAVSGRHln-vaGWKKGLVS 354
gi 153892022 284 LLLMLVSLALFMLALhw-imSPTLAITLVIALTVHECGHLLGMRLFGHrDTQLLFLPfFGGAAVAHDplvlaPWKHLVIL 362
gi 83649451  271 ALLLLVSLGAFMLSFgf-rmDAPVLLILVAVLFLHEFGHLLAMKVCGFrDLQILFIPfLGAAARGDKdq-apAWQKVIVD 348
gi 163725912 235 IGRFILSAAAFVAAFtw-lwSFENALLLLLVIFIHEIGHYLAMGLFGYkNRQVFFVPfLGAATMGAKdd-atIMQRVWVL 312
gi 89894538   98 FATTAVSMVATIWIYav-fyGAKFALGFVALLFVHEMGHYLTAKRVGLaVSGPVFIPfVGALIGMKEnp-kdAVTEAQVA 175
gi 153953019  99 FASTLISMLLMILVYak-iyGWAFGLGFVVLLFVHEMGHYLSAKAVKLdVTLPLFIPfVGALISMKEep-kdAVTEAKVA 176
gi 134299672  72 FAGTIISMALTIVIYaq-vyGWFFAIGFVASIFVHEMGHYITSKKIGMnVTAPMFIPfIGAFIGMKEap-rsVKEEALSA 149
gi 42780644   38 VFSMFLSLGAYAVIY-----GWQFGVALIYLLFIHEMGHLWAAKRKGIpTSPAIFIPfMGALIGMKEmp-knAKDEAYIA 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                      #       #                         
gi 75543517  263 LMGAGFSAFLVPIAIAASafagseghkaaaalLAALAGCAALFNIANLVPVWKFDGGQVLRQICPgpvalaLASFFLLSA 342
gi 90022952  208 MMGPVYGLIMTVVFYLIYsftg-------shfAGLVASISALLNLFNLLPVHPLDGGRVIKALVFsyrnywALLILLTLS 280
gi 87308431  355 MAGPVPGIFVGGAIGIWAlfqp-------adwKFQLALATLLINGLNMLPILPLDGGAFWQAILFcrhrflDVAFRGAAI 427
gi 153892022 363 FLGPLPGIFIGIGMMLWStgdp------tlswIWDAGLLTLIFNAFNLLPILPLDGGQIADVALLsrvphfRALFMILSA 436
gi 83649451  349 LMGPAPGLILGIALCFYLplda-------pdwMTRAVFMLIVLNYFNLAPVQPLDGGQLWNLLFFrrwpmaQFIFFCLSI 421
gi 163725912 313 LGGPAPGLLLGVICMLLFfhth-------ndfMLMLGAMFLVINYLNLLPITPFDGGKILDALFFdrfpraQFFFFLGSI 385
gi 89894538  176 YGGPLFGSLAAVLCLAFYwltg-------yelALVLAYVGFFLNIFNLLPVHPMDGGRIVSAVSPy-----LWLVGIPVL 243
gi 153953019 177 IGGPLIGSLGALICFILYfslk-------enfLMALAYTGFMLNLFNLIPLHPLDGGRIVSAISPk-----LWLIGIPIA 244
gi 134299672 150 LGGPLAGAFATLICLTFYyltk-------tpyWVGLAYVSAFLNLFNLLPFGPLDGGRITKALSPm-----IWVIGLVLT 217
gi 42780644  112 YMGPLFGLLSFLPAIPLYmitk-------epfWALIILLGSMINFFNLIPVSPLDGGRIISVVSTr-----IWGAGLVLL 179
                        170       180
                 ....*....|....*....|....*
Feature 1                                 
gi 75543517  343 FLAVGWEagf--ssgFLLATGAVFS 365
gi 90022952  281 AGCAVLSamf--gfyFLVFFIVLGV 303
gi 87308431  428 AGLGLIAlat--gsyLFGFIGITMA 450
gi 153892022 437 LGLIALGalsggaaiILTLLGLFML 461
gi 83649451  422 LAFAAFSwws--qeiVLGLVALFWM 444
gi 163725912 386 FILASCGlll--sepILLFIAVIFS 408
gi 89894538  244 LYLMITSfn-----pILLIVVILGV 263
gi 153953019 245 AIALFKFfn-----pIILLLLVLGI 264
gi 134299672 218 IVLIIKLks-----fILVLVLIVGI 237
gi 42780644  180 LGYSIYFks-----iLGGFIFIIGC 199

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