Conserved Protein Domain Family
S2P-M50_SpoIVFB

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cd06161: S2P-M50_SpoIVFB 
Click on image for an interactive view with Cn3D
SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) is one of 4 proteins involved in endospore formation; the others are SpoIVFA (sporulation protein, stage IV cell wall formation, F locus, promoter-proximal A), BofA (bypass-of-forespore A), and SpoIVB (sporulation protein, stage IV cell wall formation, B locus). SpoIVFB is negatively regulated by SpoIVFA and BofA and activated by SpoIVB. It is thought that SpoIVFB, SpoIVFA, and BofA are located in the mother-cell membrane that surrounds the forespore and that SpoIVB is secreted from the forespore into the space between the two where it activates SpoIVFB.
Statistics
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PSSM-Id: 100082
View PSSM: cd06161
Aligned: 86 rows
Threshold Bit Score: 122.265
Threshold Setting Gi: 160914224
Created: 23-Jan-2008
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
active siteputative
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                               ##  #                                    
3B4R_A        15 IELHITFILFLVVIIGLSimnnsifWAVLFILLFVSVVLHELGHSYVAKKYGVkIEKILLLPIGGVAMMDKIP---KEGE 91
gi 158320786  10 EVKTSYSIIFILIFSMIFn------YFYKLLILIAVVFLHELSHCFMCIYYGIqVKEIKLFVFGGVAKFLGDIegnSKQE 83
gi 160914224   7 KLCISKLWLVALPLFIYLh------LTKYMCFIFLILSFHECAHILVAWLMGYeFEKIVIYPFGLSASIRNIGhgkLIKE 80
gi 20807389    2 KVKVHFSTFVFGLLLIFLg------FVKELFSIFLVVCVHETGHVLAAKKLKVeVLEVNIYPFGGVAFLDPTVfirPDLE 75
gi 150015391   1 MKKWYMVLILELSILMWLg-----dYEGYIVISFLWVILHEFAHMIVASKFGCkFNNVNISIFGAKVELSDIDeltERKK 75
gi 153953509   1 MIKINKYFIPYIILLIVVg------YRGQIIYTAIVVFFHEIIHYLFSRYYKFsGFGIEFIAVGAVIKLKDLDeafPKED 74
gi 28211684    1 MIKINKYFLPYVIILLMLg------FREKIIISFILVFLHELVHCLVAKALGFkGFNIEILPVGAVLKLKDIDeasAKED 74
gi 118444773   1 MIKISKLSIPYIIILLIIg------FKGKMIVSFIFVFFHEMVHYITAKKLGFkGFGIEILPIGAVLKLRDLDeadPKED 74
gi 148380944   1 MVKINKYFIPYVVFLFYLg------YKGSFLLSISVVFVHELIHYVTARYLGFtGFNIEIYPLGLSLKLDKLEnanFKED 74
gi 81530594    1 MFKLSKYFIPYMIILFFIg------FRGEIFSVVILVIIHEFTHYLTARMFGFsGFDIEILPFGAVLRLKKIDyatQKED 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                        #       #                       
3B4R_A        92 LRIGIAGPLVSFIIGIVLLIVSqffdiningypLLYTLSLLNLMLGGFNLIPAFPMDGGRILRAILSkkygylKSTKIAA 171
gi 158320786  84 IAIALAGPLLNFILILISFAVLrlgnk--pwqeNMEFFITVNLSIGLFNLMPMLPLDGGRVFRGLLApylgikKATYMVI 161
gi 160914224  81 IVIIIAGPLSQLVFVVLFPHWAsigl---isdgFAKYLKMINANIMVFNLLPIYPLDGGRLLQSFFHsfltyqKAQKWTL 157
gi 20807389   76 ILIALAGPFFNIFFAFLSELFSqif------diRLDYFIKANLIMAFFNLLPGLPLDGGRILKSFLSyflslrSAILVST 149
gi 150015391  76 MILYLAGPFFNIFMAVVMCYLYgyf-----kyqIIEDSIKVNFFLGAFNLLPAYPLDGSRVCEILLSkkllykRSKKITE 150
gi 153953509  75 LIISISGPIFNLIFSGLFYFMYkiv-----ysnFCYVFFSINLAIGLFNLIPAFPLDGGRILRSILNlkipyrMANKITI 149
gi 28211684   75 LIIALSAPLLNIFLGVLFYFLYrih-----gheLLYIFFQYNMVIGGINLIPAFPLDGGRIVRDIIRgktvykVANKITV 149
gi 118444773  75 LIISLSGPLFNLIFAMIGYFLNikf-----sseYLQLLYISNLALGTFNLIPALPLDGGRILRDILAmktfykRANKITV 149
gi 148380944  75 LLISLSAPIVNIFFAIIFCIAYgvy-----nnnSLYLLYKSNLIIGVFNLMPALPLDGGRILRDLLCfktfyrRANEITI 149
gi 81530594   75 IIISLSGPILNLILAVIFYVIFkns-----grhIYYSLYFTNLSLGLFNLIPAYPLDGGRIMKEVLSekipyrKANEVSI 149
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
Feature 1                                                       
3B4R_A       172 NIGKSLALIMLLFGLls-------mnIILILVSLFVYFGAEQESRVV 211
gi 158320786 162 RLGYILCILLFSIGIyltfv--ynieYAFLSALAVYIGLSNAKEKSR 206
gi 160914224 158 ATSMAILLGIVVSSLlkgwsalvielFLAVQLIMTWLQLPYDRLAFY 204
gi 20807389  150 YGTYLISFSLLWVSFkdisq--vsrnVLYTFLAVLLVIAANKEKKMS 194
gi 150015391 151 IFSFIISGTLFLIFIiimil--hkvnISLFLAVILITYATFIEKEKT 195
gi 153953509 150 VISIIIGIMLMLVYVflfln--ghnnFTIGIIATFIMTTSLKENERT 194
gi 28211684  150 YISIFIGIILMGIYLflffa--gnnnISLGIIALFIMISSLNEKNRM 194
gi 118444773 150 NISLVIGMLIYVYFCistvl--gmknISIGIIGIFIVIISYKEKERI 194
gi 148380944 150 NISIGISVFFMVLYIflfmk--gynnFNLGIISLFITGFSLKEKERV 194
gi 81530594  150 YISIVIGIIFCIFSIvglff--svksINMLVVAFFILFCSFKEKGRM 194

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