2R6H


Conserved Protein Domain Family
NADH_quinone_reductase

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cd06188: NADH_quinone_reductase 
Click on image for an interactive view with Cn3D
Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase, and has NADH and FAD binding sites. (Na+-NQR) is distinct from H+-translocating NADH:quinone oxidoreductases and noncoupled NADH:quinone oxidoreductases. The NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding domain of the alpha/beta class and a discrete (usually N-terminal) domain which vary in orientation with respect to the NAD(P) binding domain. The N-terminal domain of this group typically contains an iron-sulfur cluster binding domain.
Statistics
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PSSM-Id: 99785
View PSSM: cd06188
Aligned: 20 rows
Threshold Bit Score: 298.449
Threshold Setting Gi: 91201032
Created: 2-Apr-2008
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 16 residues -Click on image for an interactive view with Cn3D
Feature 1:FAD binding pocket [chemical binding site]
Evidence:
  • Structure:2R6H: Porphyromonas gingivalis W83 NADH:ubiquinone oxidoreductase binds FAD, contacts determined at 3.5A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                             #                          
2R6H_A         1 SNAVFGVKEWEc--------eVLSNKNVST-FIKEFVVKLPege-txnFKSGSYAQIKIPKyn-----irYADYDIq--- 62  Porphyromonas g...
YP_001530422 123 PEAIFSIRKYTa--------tVVSNKNVAT-FIKELVLRIDnde-tieFEAGQYMQIDIPEyds----vcFAGFDVa--- 185 Desulfococcus o...
ZP_00531006  124 PEEIFNIRQWEc--------tVRSNSNVAT-FIKELVLQLPene-kleFRAGGYIQIDIPEyse----ilFSDFTIg--- 186 Chlorobium phae...
EDQ05432     122 PESLLTAQTWEc--------tVVSTRTIAP-IIREIVLAPSsdt-aftFEPGAFVQIEAPTyd-----ltFADYDIa--- 183 Oceanibulbus in...
Q9Z723       130 EERYLNASSWEg--------tVISNDNVAT-FIKELVVAVDpnk-pipFKPGGYLQITVPS---------YKTNSSdwkq 190 Chlamydophila p...
YP_008532    162 DEHALGVKEWVa--------tVLSNDNVAT-FIKELIVEIPege-evpYQSGGYLQFHVPS---------FKTNTEnwkt 222 Candidatus Prot...
YP_001760708 347 LLYITQAEKHQl--------eLISSEFISP-FIKELRFKTVsgk-pitFKAGAFMRFFIPAa-------sSHSLPVal-- 407 Shewanella wood...
YP_996891    471 CLNVLQAGGAGarkpgshalrVLGSRHVAT-FIKELVLEPVdpaqslaFVPGDYLQLDIPAyge----iaLRDLDVp--- 542 Verminephrobact...
ZP_01449715  334 VNTDRNIENHEl---------VVVATNFITpFIKEVKFKVKsgk-qlaFKAGAYMQFDVPAgmnslrpenMPENYE---- 399 alpha proteobac...
YP_001474014 337 LVDVTEAETHEl--------eLISSEFISP-YIKQLRFKAVsge-tleFRAGAFMRIFIPAakg---ssiPAYLPV---- 399 Shewanella sedi...
Feature 1                                             ####                 # # ###             # 
2R6H_A        63 ---dRFRGDWDKxda------wslTCKNEEETV----RAYSXANYPa----eGNIITLNVRIATPPfdraankwkagiKP 125 Porphyromonas g...
YP_001530422 186 ---dRFTSAWEQfdl-------tgLCVTADEPVf---RAYSLANPPy-----EELLRFTIRIATPPpgt------ddiPP 241 Desulfococcus o...
ZP_00531006  187 ---kEYRDDWDKftm-------wqLVSRNRESTf---RAYSMANHPa----eEGVIILNVRIATPPpdkw-----ekvSP 244 Chlorobium phae...
EDQ05432     184 ---pAHRSAWDQqgl-------daLRAQSKSSVs---RAYSIANNAla---dAGRIVLLVRLALPPpqn------pdaPP 241 Oceanibulbus in...
Q9Z723       191 tmapEYYSDWEHfhl------fdqVIDNSQLPAdsanKAYSLASYPa----eLPTIKFNIRIATPPfingk--pnseiPW 258 Chlamydophila p...
YP_008532    223 tmnpKYYADWEKfglfgkeidfshLPQKPNEVI----RAYSMASYPa----eGRKLIFNIRIATPPfvngk--mqndvPW 292 Candidatus Prot...
YP_001760708 408 --peSLSAHWKEie---------sHQFTHDSCS----RNYSLANSDnalpnaEKELHFTIKLQQAPkfat----sqviNP 468 Shewanella wood...
YP_996891    543 ---aPYAQAWKEqgl-------fdLVARHQEPAaarrNNYSLASNAa----lERPLRLNVRIATPPagq-------dcPV 601 Verminephrobact...
ZP_01449715  400 ----KYWESYSH------------GRFSHDGVT----RHYSLVNFDe----eSDELTFNIRWQTAKdg---------fRA 446 alpha proteobac...
YP_001474014 400 ----ELLHHWQD------------VIHMEYEHLac-sRNYSLANGDg----qSDELVFTVKIQTSPne--------rvKP 450 Shewanella sedi...
Feature 1        ####                                                                            
2R6H_A       126 GISSSYIFsLKPGDKVXXSGPY-GDFHIQDTDAEXLYIGGGAGXAPLRAQILHLFRTLKTgRKVSYWYGARSKNEIFYEE 204 Porphyromonas g...
YP_001530422 242 GIGSSYVFnLKPGDRVTLSGPY-GDFLVKPTGREMCFVGGGAGMAPMRSHILHQLNTEQTkRPITFWYGARSVQEMFYHE 320 Desulfococcus o...
ZP_00531006  245 GIGSSYIFnLKPGDKVRISGPY-GEFFIKESDREMVYIGGGAGMAPMRSHIFHLFKTMKTrRKVSFWYGARSKKEMFYDE 323 Chlorobium phae...
EDQ05432     242 GVVSSWLFgLRKGDPVSVTGPF-SSFAARTTEREMVFIGGGVGMAPLRAIISDQLERRNTgRKMSYWYGARSRVDLFYDK 320 Oceanibulbus in...
Q9Z723       259 GVCSSYVFsLKPGDKITVSGPY-GESFMKDDDRPLIFLIGGAGSSFGRSHILDLLLNKHSkREIDLWYGARSLKENIYQE 337 Chlamydophila p...
YP_008532    293 GICSSYAFgLKPGDKIRLSGPY-GESFMIHDERELVFLIGGAGSSFGRSHILHLFNTVKTsRKLTMWYGARSLKENIYQN 371 Candidatus Prot...
YP_001760708 469 GVGSHYICnLQPGDRVEAAGPFeEFSAQPISERSMVMIGAGSGMAPLKSLIEEQIVKLKStRPIHLFFGARNEADLIYQQ 548 Shewanella wood...
YP_996891    602 GIGSAYMFaLKPGDQVTAIGPF-GDFHIKPTRREMVYIGGGAGMAPLRAHLSHLLETENSaRKISFWYGARSRQELFYDD 680 Verminephrobact...
ZP_01449715  447 GIGSSYLGsLQVGETITAKGPFsDFYATSNKKVSRVFIGAGSGLAPLRSIIFEQLKKHKDkSGLTLIYGARTEDDLLYHN 526 alpha proteobac...
YP_001474014 451 GIGSSYICnLAPGETIEAVGPFeEFYALPSSSKPMVLIGAGSGMAPLKALIEEQLIKNSSsRELYFYFGARRQIDLIYSE 530 Shewanella sedi...
Feature 1                                                                                        
2R6H_A       205 DFREIerefPNFKFHIALSDPqp-----------eDNWTG----------YVGFIHQVIYDNYLKDHd------------ 251 Porphyromonas g...
YP_001530422 321 EFTKLaeqyDNFSYHVALSDPrp-----------eDNWQG----------MTGFIHQCLYDHYLKDHa------------ 367 Desulfococcus o...
ZP_00531006  324 EFRAIagefPNFSYHVALSDPqp-----------gDDWDG----------PTGFIHNVLNEHYLKDHe------------ 370 Chlorobium phae...
EDQ05432     321 EFERLqakyPNFRWTVALSDPap-----------eDNWQG----------ETGFIHEVALRTALAAHp------------ 367 Oceanibulbus in...
Q9Z723       338 EYENLerqfPNFHYHLVLSEPlped------iaagWDKDDp--------tKTNFLFRAFNLGQLSRLd------------ 391 Chlamydophila p...
YP_008532    372 EYEKLekeyANFAYRLVLSEPlp-----------eDLEKGwpak---dpiKTNFLFKAFEEGQLKKMd------------ 425 Candidatus Prot...
YP_001760708 549 RFTALalehTHFFYYPVLSRPtrlfngsepasssiTNHDGadqsrdnsapTQGYVQDRLAAQLDEISkqa---------- 618 Shewanella wood...
YP_996891    681 LFGALaqkhSNFSFHLALSAPla-----------qDAWTG----------LTGPVDQVVLQQYLRTHp------------ 727 Verminephrobact...
ZP_01449715  527 ELKSLsekhKNFSYIPTLSNPs-------------EQWQG----------HSGYVQQVLLPYLSQKMa------------ 571 alpha proteobac...
YP_001474014 531 HFQQLsdqyPNFHYLPVLSRPe-------------QDWCG----------ATGYVQDKLALNLQQLLldkqlkdcdqvkl 587 Shewanella sedi...
Feature 1                                                          #
2R6H_A       252 -------------aPEDIEYYXCGPGPXANAVKGXLENLGVprNXLFFDDF 289 Porphyromonas gingivalis W83
YP_001530422 368 -------------dPAEIEYYLCGPPLMIDAVMTMLDELGVepDMIAYDSF 405 Desulfococcus oleovorans Hxd3
ZP_00531006  371 -------------ePEEIEYYMCGPPIMISSVDRMLYSLGVekEMIAYDEF 408 Chlorobium phaeobacteroides BS1
EDQ05432     368 -------------aPHDCEYYLCGPPMMIKAVRAMLDDLGVgpDHIFNDDF 405 Oceanibulbus indolifex HEL-45
Q9Z723       392 -------------nPEDYLYYVCGPPLHNSSILKLLGDYGVerSSIILDDF 429 Chlamydophila pneumoniae
YP_008532    426 -------------yPEESLFYVCGPPMHNKSVLKLLDEYGVprENIILDDF 463 Candidatus Protochlamydia amoebophila UWE25
YP_001760708 619 ------------dgLANVEFYLCGPASMMTTTIEQLKARGVkeSAIAFDSF 657 Shewanella woodyi ATCC 51908
YP_996891    728 -------------dPRACEYYLCGPPAMVRACCGMLGALDVpgQQIAYDEF 765 Verminephrobacter eiseniae EF01-2
ZP_01449715  572 --------------LFPIEFYLCGPEAMMSEVEKIITDAGIpsNQIFKDKF 608 alpha proteobacterium HTCC2255
YP_001474014 588 asnqqdveikshrqIETVEFYLCGPAPMMESTIELLESHSVadSVIAFDKF 638 Shewanella sediminis HAW-EB3

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