Conserved Protein Domain Family
flavin_oxioreductase

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cd06189: flavin_oxioreductase 
Click on image for an interactive view with Cn3D
NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN, or riboflavin via NAD(P)H. Flavin is used as a substrate, rather than a tightly bound prosthetic group as in flavoenzymes; weaker binding is due to the absence of a binding site for the AMP moeity of FAD.
Statistics
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PSSM-Id: 99786
View PSSM: cd06189
Aligned: 59 rows
Threshold Bit Score: 234.751
Threshold Setting Gi: 74317788
Created: 11-Feb-2008
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 16 residues -Click on image for an interactive view with Cn3D
Feature 1:FAD binding pocket [chemical binding site]
Evidence:
  • Comment:contacts lie primarily in N-terminal region
  • Comment:based on Acinetobacter sp. Benzoate dioxygenase reductase (1KRH) and Methylococcus capsulatus Methane monooxygenase (1TVC)

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                          #          ####             ### #   ###       
1QFJ_A         5 CKVTSVEAITdtVYRVRIVPda----aFSFRAGQYLMVVMDErdkRPFSMASTPdekGFIELHIGASeINLYAKAVMdrI 80
gi 89093773  107 CDITANEKLNhdVYRIRLRMpatasmsAEYFAGQYLDMYLPDgqkASFSIGSAPdagRDLELHIRHVpDSELSTAILdhL 186
gi 94499752  103 MQIESVKPLNdfTYQVQLLSpag--klPQYHAGQYLELLIDDn-qYPFTIASKPn-gRHIELHLGVSeDNASSIAIRnyL 178
gi 152997988   6 ATVNAVESINpnVYQITLKVd-----dLTFEAGQYLIVALPTgeqVPYSIGSAPhelPYLTLYVLVSdSASLASKVVehI 80
gi 88800928   13 ATVHDIKPLSgdVWQVLLKPlt----nYPYQAGQYTELLIDGfqfLYFTIGSAPh-tPCVELHIQGGsETNNRLIEH--L 85
gi 26991888   95 CSVSECVDVGgdVWRVRLRApag--kpLRYHAGQYLMIEREGgkqAAFSLASAPhagRELELHVLAR-EPSAVQLIDq-L 170
gi 83643190  102 FQIKAVTALSddVYQVQLLApag--alPEFFAGQYLELLAPGveaAFFSIANAPg-tREVELHIQVHqESRSALAIYqyL 178
gi 87120291    6 AKVNKVELINqnVYQVSLDVp-----vDSFIAGQYLMIHLPSgesVPYSIGSAAhelPSLQLYILVAdEASLAFKVIsyL 80
gi 149376994 103 AKVVDVRSIShdVYRVELQLprr--reLSFHAGQYLSVNLPDadpCYFSIASSPs-eDLIELHIQATpEWVSAQKVIdaL 179
gi 54298933    8 AQVEDISPLTdsIVRLVLMPde----yVDYQAGQYLQILFANd-aFSYSIANAPlgsHRYELHIRHSqDNDYHQSLLahI 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                            #  #                                        
1QFJ_A        81 LKDHQIVVDIPHGEAWLRdd-----eeRPMILIAGGTGFSYARSILLTALArnpnRDITIYWGGREEqHLYDLCELEALs 155
gi 89093773  187 LNEKTVEIELPKGDCYLQahsi--gadTRLIMAAASTGFAQIKSVVEHLLAnqfsNQIHIYWGARVEeDMYLEKLPEQWa 264
gi 94499752  179 QNHSTVRVKLPGGNVWLKpgmdsfnlhDPLIFVVAGTGFAQAKAMIEDQLEhq-hSAIYLYWINRDQ-DGFYSNLPQQWh 256
gi 152997988  81 KSNNSITIKAPGGDCHIAngal-dstpENILLIAGGTGFAQIKSLYSHLVEqnftGNVSFYWGLRTPeDVFAQEWLEEAh 159
gi 88800928   86 KQNNAVDLAPANGRCTLDylp---esaSPLLLIASGTGFSQVKSIAEHLIHiqstRKVFIYWTSYKLsQLYMLERAEAWa 162
gi 26991888  171 RRDGLARIEMPFGDTHLAel-----pdGPLVLIAAGTGMGQMHSLVEHCRAqgfkHPVHLYWGVRRPeDFYQIEHWDEWq 245
gi 83643190  179 TSESVVRARLPLGKCFISgv-----pdMDVSLIAAGTGFAQIKSIVEYLLAqgfeRKLSIYWGVRQSqEMYARALSEAWa 253
gi 87120291   81 KDNENVNLKIPGGDCHIDngal-kdsvDQVLLVAGGTGFAQMKSMYDALTEqkyqGKVSLYWGVRTPeDSFLVDWIESQd 159
gi 149376994 180 TSGGEVTVELPHGRACLAsa-----pdKPLLLVAAGTGFAQMKSLVDYLQKtsydKPVKFYWGVRRHeDMYLRSLAQQWq 254
gi 54298933   83 KQYGSLRLRLPLGECSIDqlh----pqKPILFIAGGTGFAPIKAMIEQLLAdsdsRPFELFWGARSQsDLYMDEKVRSWg 158
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
Feature 1                                                                                    # #
1QFJ_A       156 lkhpGLQVVPVVEQpeag--wrgRTGTVLTAVLQDHg---TLAEHDIYIAGRFEMAKIARDLFCSERNareDRLFGDAF 229
gi 89093773  265 aehpNVHFEPIVSEpekspgwngRTGLLPEAILEDFs---DFDDVEIFTSGSPAMVYALLDACEARGFk-eENMHSDVF 339
gi 94499752  257 e-dkLIHYVPMTPEqvdg--pfySDQNVEELVQKQVs---DISRIRVVACGSPNFVYSVLDGLENKGFe-qRQMLSDVF 328
gi 152997988 160 k-ytPFTLDVIVNEkgdk--whgRSGWLYEAVLADHp---DLSKSVAFISGSVGMVYGTLDQLELKGLs-kENCFSDVF 231
gi 88800928  163 eqhaNIHSAMLISEhshw--edkHQMLVHSILADHS----DIGQCQAVTCGSPEMVYTVLDTLCEHGFr-eENMIADVF 234
gi 26991888  246 r-lpNLFLHQVVSDlcg---wegRCGMLHEAVCEDIa---DLNSVHVYASGSPNMIYATLDALVEAGMd-aHRMRADVF 316
gi 83643190  254 erheNVSFTPVMADnrd----neWQGHHAELVRAVLaerrHWDNSLVYVSGSPTMVYTAMDALAPLGLp-gEQFFSDVL 327
gi 87120291  160 ----NISLVANEAEadw----qgTTGWLYEKIVADNp---DLSRSVAFVSGSPGMVYGTLDKLEEAGLa-hDASFSDVF 226
gi 149376994 255 eewpPFTFLPVVGDded----neWSGHHDQLVRTVLasgmDWNNVEVHASGSPTMVYTLMDALLEVGLp-qEAFFSDVL 328
gi 54298933  159 shasHFQYFSLLSDk--------SEDTLASRVLARHa--nILRDWQIVISGPFDMVYSTRDTLVGYGIs-pTQMFSDAF 226

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