Conserved Protein Domain Family
FNR_N-term_Iron_sulfur_binding

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cd06194: FNR_N-term_Iron_sulfur_binding 
Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an N-terminal Iron-Sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently bound FAD as a prosthetic group) are present in chloroplasts, mitochondria, and bacteria in which they participate in a wide variety of redox metabolic pathways. The C-terminal domain contains most of the NADP(H) binding residues and the N-terminal domain interacts non-covalently with the isoalloxazine rings of the flavin molecule which lies largely in a large gap betweed the two domains. Ferredoxin-NADP+ reductase first accepts one electron from reduced ferredoxin to form a flavin semiquinone intermediate. The enzyme then accepts a second electron to form FADH2 which then transfers two electrons and a proton to NADP+ to form NADPH.
Statistics
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PSSM-Id: 99791
View PSSM: cd06194
Aligned: 21 rows
Threshold Bit Score: 219.833
Threshold Setting Gi: 163851454
Created: 2-Apr-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
Feature 1:FAD binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                    #          ####              # # # # ##             
gi 170727101  96 IHEKQYLSDsVVKILVEPsEEVSHSAGQYINLRRFDGLtRSYSITNDPDs-kLIELHIRRKYNGQFSDWLFNhasVGESL 174
gi 127512432  96 IQEKQFINEaVVRVRLVLdEPLAHHPGQYINLRRFDGLtRSYSPTSLPGe-pFLELHVRRKYNGQFSDWLYHhagIGESL 174
gi 53757052   96 VTALEPLNSeIMHVSLEChAPLEYRAGQFINLFREPTLgRSYSLASVPQhdeHLHLHVRRLPQGKVSGWIHEhlrIGQTV 175
gi 170724940  95 VAAITPLSKrILSITLDPdTPLEYHAGQFINLRRSDGLtRSYSLASHPAqgdMLEIHVQRIDNGGMSQWIHEqlsLDDKL 174
gi 108757745  96 IQALSLLSTsVLRVRLVTdSPLAYHAGQYISLVREDGLaRSYSLASLPHe-dALELHVRLQPGGAMSGWLAHdaqPGDRL 174
gi 167623600  96 LVERQFVSDsLMKLVIKLsERLDSLPGQYINLRRFDGLtRSYAIVKCLEg-nLIEMHITRKHNGQFSNWLFGtasVGEQL 174
gi 146281533 125 VQSLERLGAdVLRLRLLPeRPLRYRAGQHLLLWTAAGVaRPYSLASLPNedpWLEFHIDSSRPGAFCDFAREl-rPGDLL 203
gi 149919561 105 LEGLERLSPsVMRVRVRPdAAFAFEAGQYVALRRADGVtRSYSIASLPGe-dCLEFHVRRVPNGRMSGWLFDeaeVGARV 183
gi 52842744   96 IMSLQRLNHnVIQVKLNVeHPAPWLPGQYLSLINPEGTmRNYSIANIPAddgYIELHIKIYPQGKMGQWLLQraaINTFI 175
gi 119775242  95 LLDKLSLSEdVTRLIIKPdTRTPYIPGLCTGIRGPEGLgRTYGIAPGQGe-gTFAVHVRRKRNGRFSRWLCDevkVGGSL 173
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                      #                                                 
gi 170727101 175 LIQGPWGDCCYRs----eYKNDTLILIGTGTGLGPVYGIIRDALSQGHKGEIYLYHGAKNeaDLYHHSKLLKLmlehrNM 250
gi 127512432 175 LVQGPLGSRYYRt----aYRDAKLIIVAFGSGLGVAHGMLMQALAQGHQGEIFLYVGARDdnDLYLHPKLLKMmlehrQF 250
gi 53757052  176 EIRGPSGDCFYVp----gRPEQELVLIGTGSGLAPLYGILRDALQRGHSGPIRLFHGSRNraGLYLTDRLRELareypNF 251
gi 170724940 175 ELCGPFGHCYYQk----eMQTMPMLLVGTGSGLAPLLGIVKDALHHQHQGPIHLYHGSRTadDLYAQQLLTSLarqydNL 250
gi 108757745 175 QVQGPAGSCFYVp----gRPEQPLLLAGTGTGLAPLYGIVRDALAAGHTGPIWLFHGARTpeGLYLTSELRALaeqhpQF 250
gi 167623600 175 LVQGPLGQCIYKa----eYQTDKLILIGHGSGIGAAVGIVEHALALDHQGDIYLYHDARYiqDLYLHSALLKLslankQF 250
gi 146281533 204 RLGELHGGALHYep---eWCERPLLLLAAGTGLAPLWSLLRESLRQGHRGPIRLLHVCRQ--GHYLKEPLQALarahdNL 278
gi 149919561 184 AVSPPLGTCRYPaqpdaaYLDSPMLLVGVGTGLGPIWGIVRAAFEAGHRAPITLVQAGRTldSLYLGDELDALsaahpGL 263
gi 52842744  176 TIRGPFGQCYYHnp---hNLAFDILLAGTGTGLAPLIGIIRSALTQKHEGTITLVHGGVTdeDIYYKEELEMLsllfsNF 252
gi 119775242 174 SLTRPWGRCNYDg----aYGNDELIVVAFGTGIGPALGLVQSALDSGHQRPISLYHWGKYldDLYLHRTLLKLmlehkVL 249
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
Feature 1                                                                                     
gi 170727101 251 TYLACVeqmgsgksstrvqtgdpfevamsfhqfdsqtLSDSPQRVFLCGEPnFVNKGQELVFLNGtpldRIHALSYE 327
gi 127512432 251 HYQACItgqseskgrrvi-------hanpfsealkchQFDRQQHLFLCGEPgLVNESREIAFLNGfpieRIHSLSFE 320
gi 53757052  252 DYVPCVsgeepapglaa---------graheiafmeiPDFKDKRLFLCGHPeMVSAAKRRAFLAGaamkDIYADPFN 319
gi 170724940 251 HYLGCVsgtqaeekdri----------radelalknhQNLSGWQVYLCGHPdMVNKMKKRTYLAGadikNIFADPFI 317
gi 108757745 251 LYRPGVleggsrdvaeg----------aldvliraecPKPLGWRAWLCGDGpLVLSLRKKLFLAGlslkDLHTDAFL 317
gi 167623600 251 NYQACItskaqseqrlpsrc----tygqaadiaaqqhPIGRDCRVFLCGEPlAVNQAQQQAFLDGfeytNIHVLPFE 323
gi 146281533 279 QLEWISheerdr-------------------mlstlrPTSRRDVALVCGGPsFVDVCARRLYLAGlprgQIFGDAFI 336
gi 149919561 264 DLRRCVleepsegesstplevgavdalaprlvrddreRRPGDWLALLCGDAsVVHRLRRSLFLAGlsarRIRADAFG 340
gi 52842744  253 RYDPCVlqsqglypeg-----------siekrvlthlHSPNNTKVYVCGPKeTTNKLKTRIFLAGvpstNIYSDVFL 318
gi 119775242 250 HYQGLIsassdadridnhrv----rlmdvpqilkerhELGRDKRLFLFGEPdMVAKVTEYAFLCAldmdRIHAQSFE 322

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