Conserved Protein Domain Family
FNR_like_3

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cd06198: FNR_like_3 
NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P) binding domain. The N-terminal domain may contain a flavin prosthetic group (as in flavoenzymes) or use flavin as a substrate. Ferredoxin is reduced in the final stage of photosystem I. The flavoprotein Ferredoxin-NADP+ reductase transfers electrons from reduced ferredoxin to FAD (forming FADH2 via a semiquinone intermediate) which then transfers a hydride ion to convert NADP+ to NADPH.
Statistics
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PSSM-Id: 99795
View PSSM: cd06198
Aligned: 55 rows
Threshold Bit Score: 181.686
Threshold Setting Gi: 88855869
Created: 7-Sep-2007
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
Feature 1:FAD binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                  #              ####             # # ##
gi 33592998  230 ERFADnavm----qvdVQLETRWp------------GHKAGQFAFVAFdr---aEGAHPFTISSAWRddglLRFSIKGLG 290
gi 160354384 215 YRVSEvrper-gdavtLVLDPDGhe---------gfRFRAGQFAWLTLgaspfaAREHPFSISGSSQraprVELTVKALG 284
gi 70730284  199 YQVTAvrvek--nslhLELIPQGrg----------fPFKAGQFAFLSMqek-glREPHPFTIASAQAhdgrIEFVIRALG 265
gi 149914367 208 WRVLSvtpaa-rrtwrLRLTPEGah---------rlRYRAGQFAWLTIgrppfsLNDNPFSIASAPSrgpdLEFIIKQLG 277
gi 46580765   33 AIIAEdae-----tttIVIEPASaqr--------lkAFQPGQFATLRIldddgwSVPHPFTLSGAPHq--gVRLTVRHRG 97
gi 114765830 213 RRLTRprsecwtvaslRRVTPRIhemllenphgdslDFRPGQFVWASVggqrlpLHDHPFSIASAPGap-qLRLLIQEAG 291
gi 114319254 226 IKAVEqsgp---gywdVTVEPEAdsqa------rqfRFHAGQFAWLKVaghpytLKEHPFSIASSPAalpeVVFTIKEAG 296
gi 154250549 199 YRVVKvlrgp--saaeIEFEPVKrg----------iDFHAGHFGFLRMkvd-glREPHPFTIAAAPApdgrITFVIRALG 265
gi 78356426   67 GVIVDtvren-ddttsIFFRPEDder--------fkAFRPGQFASIRVmteegwSEPHPFTISGAPGd--tLRMTIKRNG 135
gi 109896707 230 FTVVDcqkgs-addwyLTIKKDAdf---------qfEFDAGQFVWINTsgsafkRNEHPFSIASSPRslpeLSFVIRNLG 299
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         ##                                       #                                     
gi 33592998  291 DYTRSLPaRLRVGDGVTVEGPYGRFDFRan--gRPQILVAGGIGITPFLARLQDMAaarsdgapaheVDLVYSTNAp--- 365
gi 160354384 285 DFTQRVQ-ATRPGARAWVDGPYGTMSVDafpdaDGYLFVAGGIGVAPCLSMLRTLAdrgd----rrpHQLVFGTGRwe-- 357
gi 70730284  266 DYTQRLRrQVKVGMRADIYAPYGRFKRPqa--aAREIWIGGGVGISPFISWLQDEAagq-----fdkATLVYCYNPsr-- 336
gi 149914367 278 DMTDRIG-QIPPGTRVYVDGPHGHLTLTgqedaPGIALIAGGVGIAPLLGLLREMAargd----prpSLLIYGNRIpg-- 350
gi 46580765   98 HFTSQGIpRLRPGDAIKCAGPYGVFCRDia-akEDIVLIAGGMGITPFLSVLRHFArtga----dnrITLFWANRNfa-- 170
gi 114765830 292 DFTSSLD-AVEPGTRVAIDGPHGSFGPSda-prDGLVLIAGGVGIAPILSMLETFArdgc----acrLRFAYAMHDsrdm 365
gi 114319254 297 DFTNTVG-ELQPGQRAYLDGPHGHFVLDdr-paAGIMLIAGGVGIAPIMSLLRELRaqge----qrpVRLVYGVRRle-- 368
gi 154250549 266 DYTAKLIaDVEPGMEADVYAPYGRFERKpd--cRREIWIGGGVGISPFIAWMRDEQkgg-----fanVSLFYFFTPgr-- 336
gi 78356426  136 RFTGEIIpALKAGVPIQCAGPFGAFCRDie-geEQIVFVAGGVGITPFLSVLRHFRntda----ansIVLFWCNKTya-- 208
gi 109896707 300 DYTKQLG-KLQFGQRVWVDGPHGVFTLNar-naQGIVLLAGGAGIGPIIGILRGLNdrgd----trpIRLIYGNRNma-- 371
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 33592998  366 --dPDFIGELRALaera--rvgLHVLVTQRdgklsaerlv----------------dmlpraaqsEVWFCGPAGfg---- 421
gi 160354384 358 --rTPFREALAELatrl-dltvVHVLEHPPdgwtgevgvvge-----------dvlrrhlprghrGCFVCGPPAmm---- 419
gi 70730284  337 --aFPSVDTLQGMaqar--gvnFVANCGGTeplaqtlkrt----------------aaetdpqqiQVSFCGPKGll---- 392
gi 149914367 351 --qIVCEDELQALardh-gtkvIHVLSEPPkgwsgetgfvdarm--------lrrhvaeagrrdwLFVVCGPPPml---- 415
gi 46580765  171 --gAFAADELAGLtral-nlrvVHVLSRETnpdlnsdpafpavafekghidsdvvqrhvphaataSFYLCAPAEmr---- 243
gi 114765830 366 ipaAMFRPALATLg--------VTPLLTASrnaggeiaqgrlgea------qmkllldgldpkrvEVMICGPGPlm---- 427
gi 114319254 369 --eALFREELAAAeeam-dlqvFLVVDEPGdepvddpkvlrgpvtr----evlhhclpergaadwVHYICGPPAmi---- 437
gi 154250549 337 --vFPDIDVLRKMaeer--gieFVPVSGGPgsrdfidrfge--------------ivrdtapgtpDIALCGPAGllesvr 398
gi 78356426  209 --dAFAAQELEEIadti-dltvVHVLSREHkpdlyeeedkprirfek-ghfsrhmlerhirsttaSFYLCGPGPmq---- 280
gi 109896707 372 --qMMFLDELIDMtknmnlvttLVLNDAPDdfpptgfqghkgfinq----svieatgqgyntqnwDYYICGPQPmv---- 441
                        250       260
                 ....*....|....*....|....
Feature 1                                
gi 33592998  422 -qALREGLAargmppacFHQELFE 444
gi 160354384 420 -dAVETALVrlgvplrdIHSERFD 442
gi 70730284  393 -gQVRELMSecripqgnLHYEFFE 415
gi 149914367 416 -rTVEAALLelgvparrILSEQFV 438
gi 46580765  244 -rAVLAELQacgvdmscVESEDYT 266
gi 114765830 428 -tTLTDTLNdlgvplshIHYERFS 450
gi 114319254 438 -dSVENSLEaeqvplehIRSERFR 460
gi 154250549 399 glARENGLDpa-----cIRHELFQ 417
gi 78356426  281 -eHVLDEMAaygidpagVNKEQFV 303
gi 109896707 442 -kAVERTLQqleipqsrILYEQLG 464

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