Conserved Protein Domain Family
DHOD_e_trans_like2

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cd06220: DHOD_e_trans_like2 
FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to orotate coupled with the reduction of NAD+. In L. lactis, DHOD B (encoded by pyrDa) is co-expressed with pyrK and both gene products are required for full activity, as well as 3 cofactors: FMN, FAD, and an [2Fe-2S] cluster.
Statistics
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PSSM-Id: 99816
View PSSM: cd06220
Aligned: 21 rows
Threshold Bit Score: 306.097
Threshold Setting Gi: 21759368
Created: 3-Jun-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
  next features
Feature 1:FAD binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                 # ####             ###   ###           
gi 21759367    6 VTITQITEEsplVRTFFFDHRfe---dMDPGQFVMVWVrGVDEVPMGLSR------NNSITVQKVGEATSKLFELk-eGD 75
gi 9297031     7 TQIERLTDE---VATLYFSISl----rSYPGQFVMVYVpGCEEIPLSLSS------SNSVTVKAVGETTASLINAk-eGQ 72
gi 21759368    9 AEVVENREEc--ERTIVLRLRperpirWEPGQFLMLGIsGVDEKPMAFSGgd--drEFELTIEIVGPFTERCADLe-pGD 83
gi 119720066   6 ARVAEVLDLapsVKMYILELSrp--fgSQPGQYVMVWLpGVGEFPVSVAGek--ggALRLVVARKGRATGYMHERvaeGG 81
gi 161528897  11 VTVEKVIDEtptVRTLVFSDEvm--snVLPGQFAMVWIpGINELPMSVMIsde-sgKAAFTVRKHGAASTGLFNVk-vGE 86
gi 118194270   1 MEIERVIDEtptVRTLLFQDDim--egALPGQFAMVWVpGAGELPMSVMAaee-pgMAAFTVRRRGAASTGLYDTa-kGG 76
gi 84490202   14 VEIKETIIEtptVKTFIFPWNit--ddIHPGQFVMVWD-LHNEKPMTISIidrennLMGITIRKAGPFTENMYDNmdvGD 90
gi 91201892    8 VKIYDIIDEtpnVKTFFFEYAg----qYEPGQFIMVWVpLNDEKPFTISYid--gnVAGITVLKRGEFTKTLHTKk-kGD 80
gi 21759383    4 ITVDQVRDEaknVRTLFFRWDh----dVKPGQFVMVWLpGLGEIPMSLSYvg---sPKGITVKAYGKVSQAMIDMe-pGH 75
gi 126009138   4 FTIKENIMEsrdVNTLTFEDDi----kIKPGQFIMAWApRINYIPLSFSSvs---qIKSITVKIYGEASAYLAGLk-pGE 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                   #                                                    
gi 21759367   76 SFGLRGPFGKGFTLpsrGEKVLLIAGGVGAAPLSPYAEAAsaagaeVHTILGARSAg-DLLFEWRFea------lgDIYA 148
gi 9297031    73 YVGVRGAFGSAFTP---SKRALIVAGGIGIAPMKYLYEYLmkcgskVSVVYGERTAk-NLFWLDKFd---------RITV 139
gi 21759368   84 VVWVRGPYGKPFEVr--GSRAVVVAGGTGVAPLVPLVERLrrarvhVTSVLGGPHAd-RLPRKDDLekl-----sdELYV 155
gi 119720066  82 YVFVRGPLGRGFRLd--ARKALLVGGGYGAAPLLYLAERLsgagatVHAVLGFRSRe-HALLVEDFrrv-----agEVWV 153
gi 161528897  87 QIGIRGPYGNSFDLk--EGKLLLVGGGTGLVPMMRLLTHVkpt-ddITVLIGAKSK--DEVFFEDLanrllennphKVIV 161
gi 118194270  77 LIGVRGPYGRAFEAt--QGRALLVGGGTGMSPLMRLLSRLgsa-shVDVLIGAQTE--KEVFFEGLagrlagdvphRIVV 151
gi 84490202   91 LIGIRGPYGHGYELd-gYKKVLAVGGGSGIASLAPLTSFYd-----NVELISASSCadELVFNKRFds------dvVVHK 158
gi 91201892   81 QIGIRGPYGMGYGLpenNAVTCIVGGGIGMASIACLADMQk----nTTIIQGARTMp-ELLFQHRFr---------EMKL 146
gi 21759383   76 EFYIRGPYGNGFQIe--SGRKLIIGGGSGIASLLPIADSD------TDALISAKTKe-ELIFTDRFpe-------sRLFI 139
gi 126009138  76 KLFYDGIYGNGYDAv--PGKKLLIGAGSGIASLIPLIDEN------TTGIISGKTKt-DILFRSKFkk-------eKLHI 139
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                   ##                   
gi 21759367  149 STDDGSkGVKGFVTDVLKgld-vaaYDRIAVCGPEIMMASVFRLLEERKvlekAEFSLHRYFKCGIGVCGACCIDlsGLR 227
gi 9297031   140 TTEDGSfGLKGTVLDALKlek-ldeYEKIYVCGSEGMLRATYDFLKERDaldkAEFSLERYMRCGIGVCGSCVIEn-GLR 217
gi 21759368  156 TTEDGSeGRKGFPTDVLEelvekecPDVVYACGPEGMLVRVAEIAREHDv--pCQVSVVRYVKCGEGICGSCALGk-GLL 232
gi 119720066 154 ATEDGSeGFKGTAVDLFErvfpgggYDAVYTCGKELMMEKVVRRAVEAGv--rVQASLERIIKCGVGVCGACALEplGLR 231
gi 161528897 162 STDDGSyGEKGFVTDLVEkhvdqikFDGVYVCGPEIMMYKTVQSAHSRGi--fVQASLERMMKCGVGICGSCCVG--EDL 237
gi 118194270 152 TTEDGSyGRQGRVTDELEgml-dekPDAVYTCGPEPMMHAVVRAADSRGi--pVQASVERVMKCGVGICGSCCMG--EDL 226
gi 84490202  159 CTDDGScGFKGFSTQLAEellqtgeYDVIVGCGPEIMSYKLYELSIKYDv--dCQLALDRYMKCGLGICGQCCIDdtGLR 236
gi 91201892  147 CTDDGSfGYRGTTVDLLReltgqhnYKKIYACGPEKMLYKIFELCNERHi--dCEVSIERYIKCGFGICGQCDCS--GQR 222
gi 21759383  140 ATDDGSeGFHGFPHEFLDrld-isvYRKIYVCGPEPMLYRVMQKLASMNa--rAEFSLERTMKCGIGICDSCSVG--GLQ 214
gi 126009138 140 VTDDGSmGKKGFVATAMDeld-iesFDMIYVCGPEIMMFSVLNYLKGMKv--nCQFSLERSMKCGIGLCDSCSIN--GFQ 214
                        250
                 ....*....|....
Feature 1                      
gi 21759367  228 VCKDGPVFSGIQLL 241
gi 9297031   218 VCADGPVFNASELP 231
gi 21759368  233 VCRDGPVFWTEELE 246
gi 119720066 232 VCSDGPVFDGETLL 245
gi 161528897 238 VCKDGTVFDGQHLS 251
gi 118194270 227 VCTDGAVFDGKHLI 240
gi 84490202  237 VCVEGPVFNKNQLR 250
gi 91201892  223 ICIDGPVFNAEALG 236
gi 21759383  215 VCRQGPVFDIEQLR 228
gi 126009138 215 VCRDGPVFSIEKLK 228

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