Conserved Protein Domain Family
sulfite_reductase_like

?
cd06221: sulfite_reductase_like 
Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is linked to ferredoxin and reduces NH2OH and SeO3 at a lesser rate than it's normal substate SO3(2-). Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to orotate coupled with the reduction of NAD+.
Statistics
?
PSSM-Id: 99817
View PSSM: cd06221
Aligned: 36 rows
Threshold Bit Score: 235.194
Threshold Setting Gi: 119503735
Created: 22-Feb-2008
Updated: 17-Jan-2013
Structure
?
Aligned Rows:
  next features
Feature 1:FAD binding pocket [chemical binding site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                    # ####             ###   ###        
gi 18145101   15 VKKHTDIe---yTFRMEFKg---------dVKPGQFFEVSLPKFGEAPISVSGIge--dYVELTIRRVGVVTNEIFEKyE 80
gi 56412573   24 ITRHTPL-----EWNFRVAvd-------fpAHWGQFVEVSLPRVGEAPISVSDYgd--gWIDLLIRNLGKVTSALFTLkE 89
gi 83590017   17 VLAIQPQtgvdyTFRLATDi---------ePAWGQFVEISLPGVGEAPISVSDAgp--gYIELTIRRVGKVTTALHQLkP 85
gi 148323437  18 IIKHTDIe---wTFRVNADts--------kTKPGQFYEISLPKFGESPISVSGIge--dYIDFTIRAVGRVTNEIFEYkI 84
gi 18310519   12 IIDIVKEtd--kEWTFRIAsd-------vvPEHGQFLELSLPKVGEAPISVSGFgp--gYLDFTIRAVGKVTDEIFKLkP 80
gi 89091970   13 VESYVSEsp--sIFTLKLRltnaadraayqFMPGQFNMLYMFGVGEVPISIVSDpddptLIEHTIRIVGRVTQAMAKLkE 90
gi 74317279   17 VVARVEEsp--gVFTLRVRlddpgaqaayrFAPGQFNMLYLYGAGEVPISIMSDpeerdAIGHTIRAVGRVTQGLAALgP 94
gi 52842677   16 IIQRTQEss--sIFTLHFRftdeehhkqfqFYPGQFNMLYLYGVGEVAISIVSDprkktFLSHTIRAVGRVTKAMQKLqV 93
gi 67156089   11 LLEFHDEgegirHFSFALQslrs---gdqaVMPGQFFMLTVPGAGEAPFSYVRPpdwqgRFSALIRREGTVSAALFAQeP 87
gi 42526494  338 IVKIEKEsediiIITLNGKc---------kFEAGQFVFLWIPGAGEKPFSLAEAd----PISLIIKKRGPFTEALFELkA 404
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                      #                                                 
gi 18145101   81 GDKLFLRGPYGNGFDVnnykGKEVIVVAGGTGLSPVKGIVDYFSQnpkdaESFTLISGFKGPk----------dILFKDD 150
gi 56412573   90 GDNVWLRGCYGNGYPVdtlrHKPLLVVAGGTGVAPVKGLMRYFVEnpqeiGQLDMILGYKNRd----------cVLYKEE 159
gi 83590017   86 GDTVYLRGPYGSGFPRdefaGHQLVVAAGGTGVAPVKGLINYYAGhpgelAGLNLLLGFKTPa----------dILFRTD 155
gi 148323437  85 GDKLFIRGPYGNGFDLneyvGKDLVIVVGGSALAPVRGIIQFVYNnpekvKSFKLIAGFKSPk----------dVLFAKD 154
gi 18310519   81 GDKISLRGAYGKGWPVeqfkDKNVIIVAGGTGVAPVRSLINKFYDepnyvETLSLVFGFKNSe----------gILFKND 150
gi 89091970   91 GDQVGLRGPFGRGWPMalgrEKDLLIITGGLGCAPVVAAINYALQrrehyGKVSIVQGVKHSd----------dLIWEEQ 160
gi 74317279   95 GDAIGLRGPFGRGWPLrevsGSDVVLVTGGLGCAPAVSVIHYVLRrrerfGKLVIIQGVRHAd----------dLIWREH 164
gi 52842677   94 GDRLGIRGPFGVGWPLqktiGKDIIVLTGGLGCAPSVSIINYILGrrrhyGKLSILQGVKHSe----------dFIFRKQ 163
gi 67156089   88 GSRLGYRGAFGTGWPEls-gARRVLVVAGGSGLAALAGLIEALLRag-hqAALTLVYGARSPg----------hQVLARE 155
gi 42526494  405 GDTIYMRGLYGKGIKPp--kTENALLIAGGTGIAVLPALAKRLKKq---gALVSTYVGTSEEikkkepngiekiLIECGA 479
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 18145101  151 MKEWek---nmNMIITVDSAeegyeGNTGLVTKYIPEleikd-mdnvqVIVVGPPMMMKFTVLEFLKRGikeENIWISQE 226
gi 56412573  160 MATWrg---khNLVLTLDEGeaddrYQIGRVTDRLADmtlsd-idtmqAIVVGPPIMITFTVKMLLQKGlkpEQIWVDYE 235
gi 83590017  156 IERWqg---lfPTILTVDQGqagwsGKVGLVTEFVKEiplk---ndarIIVVGPPLMIKFTVAEFIKCQikpEQIWVSLE 229
gi 148323437 155 LEEWsk---klDVILTVDGAeegykGNIGLVTKYIPElkfnd-lsnvsAVVVGPPMMMKFSVAEFLKLNvaeKNIWVSYE 230
gi 18310519  151 LDRWne---kfNTIYTLDNDtk-egWETGLVTVHLNKlplesfgdnyeVIIVGPPVMMHFTALEFLKLGvpeEKIWVSFE 226
gi 89091970  161 YKEWqql-hnvEVNLAADESgpawpFHQGRITELLDKvsvdi--ansvALICGPEGMMDAAARRLLSLGmpgYSIYVSLE 237
gi 74317279  165 YDRWakl-patQVLVAADVAtplwpWHVGRVTDLFGLarfdp--egavAMMCGPEGMMRTAGNGLLALGlpeARLYLSME 241
gi 52842677  164 YAKWqks-dhtEVYIAADQAgpkwpWGVGYVTDLIDHiiiqp--dnsvVMMCGPEMMMNTAVKVFTQKGileNDIYLSME 240
gi 67156089  156 RARWre---alELIETLERRe---dGRVGCNPLEPLRsrlas-qvpdaVLCCGPEPLMRSVAELCLAHGvppTGIWLSIG 228
gi 42526494  480 YKKVadkgvigRVLNQFQKDni--eGNTGLPIQGKAEkmgkq--dfftAYLVGPMIFMRRASEILLKLGvrkSQIFMSLE 555
                        250       260
                 ....*....|....*....|....*....
Feature 1        ##                           
gi 18145101  227 RKMCCGLGKCGHCKIDDTYICLDGPVFNY 255
gi 56412573  236 RRMACSVGKCGHCRMGEVYVCTDGPIFNY 264
gi 83590017  230 RRMHCGLGKCGHCKINDVYVCLEGPVFNY 258
gi 148323437 231 RNMHCGIGKCGHCKMDATYICLDGPVFDY 259
gi 18310519  227 RKMSCAVGKCGHCRINETYVCLEGPVFNY 255
gi 89091970  238 RNMQCAVGHCGHCQMGADFICKDGPVFVY 266
gi 74317279  242 RNMQCAVGRCGHCQIGAAFVCHDGPVFSW 270
gi 52842677  241 RNMECGIGHCGHCQYGGLFVCKDGPVFAY 269
gi 67156089  229 RRLDCGMGHCGRCHVGRGSVCQEGPVYRY 257
gi 42526494  556 MNTMCGVGICGECSCGNILTCKKGTFVSL 584

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap