Conserved Protein Domain Family
REM

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cd06224: REM 
Click on image for an interactive view with Cn3D
Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately N-terminal to the RasGef (Cdc25-like) domain. REM contacts the GTPase and is assumed to participate in the catalytic activity of the exchange factor. Proteins with the REM domain include Sos1 and Sos2, which relay signals from tyrosine-kinase mediated signalling to Ras, RasGRP1-4, RasGRF1,2, CNrasGEF, and RAP-specific nucleotide exchange factors, to name a few.
Statistics
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PSSM-Id: 100121
View PSSM: cd06224
Aligned: 89 rows
Threshold Bit Score: 53.1852
Threshold Setting Gi: 74680258
Created: 8-Jan-2008
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
GTPase
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:GTPase interaction site [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                   #                                                                    
2BYV_E       492 TPEKILEHFLETirlepslneaTDSVLNDFVMMHCVFmpnTQLCPALVAHYhaqpsqg------------------teqe 553
1NVV_S        40 TVIKLIERLTYHmy-------aDPNFVRTFLTTYRSFckpQELLSLIIERFeipepepteadriaiengdqplsaelkrf 112
gi 6919956    96 TLEALVRHLLDTrts-----gtDVSFMSAFLATHRAFtstPALLGLMADRLeales-----------------------h 147
gi 14548230   73 TLEKLVENLLTAfg------dnDFTYISIFLSTYRGFastKEVLELLLDRYgnltspnce--------------edgsqs 132
gi 14549162  120 TLEKLVEHLVPAfq------gsDLSYVTIFLCTYRAFtttQQVLDLLFKRYgrcdaltassry--------gcilpysde 185
gi 74614106  607 TFDELIDRIIAPkmt-----raDNNFADIFLCLYRKFatpCELMSALLSRLdrlrdg--------------------tdm 661
gi 74845161   66 TLSRLVDALATDdg------elESTFVNVFLNTFRTFaqpEKVLELLLDRYeklhaep------------------allq 121
gi 81897723   74 MVVKLVNNLVPSlq------egDHFFVSIFLSTYRSFvtpLQVLGLLFMRYpyfh------------------------p 123
gi 82113050   52 TEEKLVLHLLHSfs------mgDSSFISIFLSTYRSFtstQRVLDILICRLenppg----------------------et 103
gi 82186165  109 TLERLVETLLTAfg------dnDLTYTSIFLSTYRAFastQSVLELLLDRYgsfedcege---------------rsqcq 167
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
Feature 1             #   ##  #  ##                                          ##  #      #
2BYV_E       554 rmdYALNNKRRVIRLVLQWAAMYgdllq---eddvAMAFLEEFYVSVSdda-----rmMAAFKEQLPELEKI 617
1NVV_S       113 rkeYIQPVQLRVLNVCRHWVEHHfydfe---rdayLLQRMEEFIGTVRgk-------aMKKWVESITKIIQR 174
gi 6919956   148 ptdELERTTEVAISVLSTWLASHpedfg--seakgQLDRLESFLLQTGyaag---kgvGGGSADLIRNLRSR 214
gi 14548230  133 sseSKMVIRNAIASILRAWLDQCaedfre-pphfpCLQKLLDYLTRMMpgs-----dpERRAQNLLEQFQKQ 198
gi 14549162  186 dggPQDQLKNAISSILGTWLDQYsedfcq-ppdfpCLKQLVAYVQLNMpgs-----dlERRAHLLLAQLEHS 251
gi 74614106  662 pslLSIESQMRVIEVVAKWLSLYpgdf----artaTRRRLEGLISDLAtnevfsaaarQMKGNLEQKVVDDD 729
gi 74845161  122 pesLSDQHKKTLVSVLHVWLDGFpedw-----dtdNLQRLLAFTSKRLpk-------sEIHMKALNRNSKRT 181
gi 81897723  124 hsvEHRQVRSSLCNFLHTWMDKNpedfcd-psdmlPLTYLKAYLSVHMphs-----elFIRVDRLLNELWEE 189
gi 82113050  104 hsnSRQIFNKAVCTVFSTWMTDYpedfrslsdpsrLLRLAPLLPTDSSg---------AEIKSRLLRIAEEL 166
gi 82186165  168 tgeSRKAVRKALASILRAWLDQCpedfqe-ppsypSLHRVLGFLQKAMpgs-----epMRRAQSLLEQLRVQ 233

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