Conserved Protein Domain Family
HAMP

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cd06225: HAMP 
Click on image for an interactive view with Cn3D
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.
Statistics
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PSSM-Id: 100122
View PSSM: cd06225
Aligned: 204 rows
Threshold Bit Score: 28.3698
Threshold Setting Gi: 74512156
Created: 8-Jan-2008
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
dimerization
Conserved site includes 19 residues -Click on image for an interactive view with Cn3D
Feature 1:dimerization interface [polypeptide binding site]
Evidence:
  • Comment:Two HAMP domains form a parallel four-helix bundle
  • Structure:2ASX: HAMP domains from Archaeoglobus fulgidus Af1503 dimerize, contacts at 3.5A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1       ##  ## ##  ## #                           ## ##  ## ##  ##  
2ASX_A        5 ITRPIIELSNTADKIa----------eGNLEAEVPhqn-radEIGILAKSIERLRRSLKV 53
gi 12644127 220 LRSRVAYLKDRMSSAaa---------nLSLRTRLEldg--ndELCDIGKSFNAFIDKVHH 268
gi 20141732 366 LVKRFTALNQAVVQIg----------lGRTDSTIPvyg--rdELGRIARLLRHTLGQLNM 413
gi 29336629  55 LALGFVLTSQVTNRVldikvraaidqiERARTTVSgiv-ngeETRSLDSSLQLARNTLTS 113
gi 47606727 211 VISRVQRIAAVSGQIe----------qGDYSVSFEhdg--ndELTRLNANLASMVTTIRD 258
gi 74512156 277 VVDRVERLAESLGRIme---------kGAGRVEVEgc----dEITLLEKRINELLDAISG 323
gi 75348919 294 TVTPLRAVTTAVQELa----------eGRTDITVPetr--vaEVRSIGAALESFRTTILE 341
gi 75422291  58 FIDRLKLIETELKRVa----------dGNLRRRLLakg--gqPFNEIIFSINELIEQLEK 105
gi 81556213 347 LSSSLNKILEYSERLa----------sGNFTADINfgkwdtvELYSLYEGLEQLRTNFSS 396
gi 81671634 182 AQRRVEEVNQRVQRIv----------aGELRERLPegg-tddPFARLAGIVNGMLDEMET 230

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